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Angoline
Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
Catalog No. TN6739Cas No. 21080-31-9
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Purity:99.96%
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Angoline
Catalog No. TN6739Alias 6-MethoxyldihydrochelerythrineCas No. 21080-31-9
Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $60 | In Stock | |
| 5 mg | $147 | In Stock | |
| 10 mg | $217 | In Stock | |
| 25 mg | $363 | In Stock | |
| 50 mg | $538 | In Stock | |
| 100 mg | $779 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $160 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation. |
| Targets&IC50 | IL-6/STAT3 signaling pathway:11.56 μM (IC50) |
| In vitro | Angoline as a potent and selective inhibitor of the STAT3 signaling pathway (IC50=11.56 μM).?Angoline inhibited STAT3 phosphorylation and its target gene expression and consequently induced growth inhibition of human cancer cells with constitutively activated STAT3 (IC50=3.14-4.72 μM).?This work provided a novel lead for the development of anti-cancer agents targeting the STAT3 signaling pathway. |
| Alias | 6-Methoxyldihydrochelerythrine |
| Molecular Weight | 379.41 |
| Formula | C22H21NO5 |
| Cas No. | 21080-31-9 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/ml (79.07 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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