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Antitrypanosomal agent 1

Catalog No. T10339Cas No. 75144-12-6

Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor (IC50: 3.3 μM) that also inhibits glutathione reductase (IC50: 64.8 μM) and T. brucei (EC50: 1 μM).

Antitrypanosomal agent 1

Antitrypanosomal agent 1

Purity: 97.76%
Catalog No. T10339Cas No. 75144-12-6
Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor (IC50: 3.3 μM) that also inhibits glutathione reductase (IC50: 64.8 μM) and T. brucei (EC50: 1 μM).
Pack SizePriceAvailabilityQuantity
25 mg$37In Stock
50 mg$53In Stock
100 mg$76In Stock
500 mg$183In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:97.76%
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Product Introduction

Bioactivity
Description
Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor (IC50: 3.3 μM) that also inhibits glutathione reductase (IC50: 64.8 μM) and T. brucei (EC50: 1 μM).
Targets&IC50
Trypanothione reductase:3.3 μM, T. b. brucei:1 μM(EC50), Glutathione reductase:64.8 μM
Chemical Properties
Molecular Weight282.59
FormulaC11H14Cl3NO
Cas No.75144-12-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 9.89 mg/mL (35 mM)
DMSO: 24 mg/mL (84.92 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.5387 mL17.6935 mL35.3870 mL176.9348 mL
5 mM0.7077 mL3.5387 mL7.0774 mL35.3870 mL
10 mM0.3539 mL1.7693 mL3.5387 mL17.6935 mL
20 mM0.1769 mL0.8847 mL1.7693 mL8.8467 mL
DMSO
1mg5mg10mg50mg
50 mM0.0708 mL0.3539 mL0.7077 mL3.5387 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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