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Azoramide

🥰Excellent
Catalog No. T4304Cas No. 932986-18-0

Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.

Azoramide

Azoramide

🥰Excellent
Purity: 99.85%
Catalog No. T4304Cas No. 932986-18-0
Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
Pack SizePriceAvailabilityQuantity
10 mg$31In Stock
25 mg$61In Stock
50 mg$95In Stock
100 mg$173In Stock
200 mg$253In Stock
1 mL x 10 mM (in DMSO)$30In Stock
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Purity:99.85%
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Product Introduction

Bioactivity
Description
Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
In vitro
Azoramide, a dual-function endoplasmic reticulum (ER) modulator, improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress in multiple systems.
In vivo
In two independent mouse models of obesity, Azoramide exhibits potent antidiabetic efficacy by improving insulin sensitivity and pancreatic β cell function.
Chemical Properties
Molecular Weight308.83
FormulaC15H17ClN2OS
Cas No.932986-18-0
SmilesCCCC(=O)NCCc1csc(n1)-c1ccc(Cl)cc1
Relative Density.1.215 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (161.91 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2380 mL16.1901 mL32.3803 mL161.9014 mL
5 mM0.6476 mL3.2380 mL6.4761 mL32.3803 mL
10 mM0.3238 mL1.6190 mL3.2380 mL16.1901 mL
20 mM0.1619 mL0.8095 mL1.6190 mL8.0951 mL
50 mM0.0648 mL0.3238 mL0.6476 mL3.2380 mL
100 mM0.0324 mL0.1619 mL0.3238 mL1.6190 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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