Home Tools
Log in
Cart

BAY-876

Catalog No. T3713   CAS 1799753-84-6

BAY-876 is an orally active and selective inhibitor of glucose transporter 1 (GLUT1, IC50= 2 nM). BAY-876 exhibits <130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 also inhibits glycolytic metabolism and ovarian cancer growth.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
BAY-876 Chemical Structure
BAY-876, CAS 1799753-84-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 56.00
2 mg In stock $ 79.00
5 mg In stock $ 97.00
10 mg In stock $ 148.00
25 mg In stock $ 273.00
50 mg In stock $ 449.00
100 mg In stock $ 659.00
1 mL * 10 mM (in DMSO) In stock $ 108.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 98.89%
Purity: 98.73%
Purity: 98.61%
Purity: 97.37%
Purity: 97.37%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description BAY-876 is an orally active and selective inhibitor of glucose transporter 1 (GLUT1, IC50= 2 nM). BAY-876 exhibits >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 also inhibits glycolytic metabolism and ovarian cancer growth.
Targets&IC50 GLUT1:0.002 μM
In vitro BAY-876 is a highly-selective GLUT1 inhibitor with selectivity over GLUT2, 3, and 4 of 4700-, 800-, and 135-fold, respectively[1].
In vivo BAY-876 displays low clearance also in?vivo in rat and in dog. The volume of distribution in steady state (Vss) is moderate in both species. Terminal half life is intermediate in rat (2.5 h) and long in dog (22 h) due to the very low clearance. The oral bioavailability (F%) is 85% and 79% in rat and dog, respectively. Preliminary in?vivo PK studies of BAY-876 demonstrate that a good oral bioavailability and long terminal half-life is attainable making it an excellent chemical probe to further evaluate the hypothesis of cancer treatment with a very selective GLUT1 inhibitor[1].
Molecular Weight 496.42
Formula C24H16F4N6O2
CAS No. 1799753-84-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 3 mg/mL (6.04 mM)

DMSO: 92 mg/mL (185.4 mM)

TargetMolReferences and Literature

1. Siebeneicher H, et al. ChemMedChem. 2016, 11(20):2261-2271.

TargetMolCitations

1. Pei Y, Lv S, Shi Y, et al. RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1. Autophagy. 2022: 1-17 2. Chen X, Zhao Y, He C, et al. Identification of a novel GLUT1 inhibitor with in vitro and in vivo anti-tumor activity. International Journal of Biological Macromolecules. 2022, 216: 768-778. 3. Zhang M, Tan Y, Song Y, et al.GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy.Biomedicine & Pharmacotherapy.2023, 161: 114324.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Anti-Cancer Active Compound Library Metabolism Compound Library Target-Focused Phenotypic Screening Library Bioactive Compound Library Ion Channel Inhibitor Library Fluorochemical Library Anti-Metabolism Disease Compound Library NO PAINS Compound Library Preclinical Compound Library

Related Products

Related compounds with same targets
Telaglenastat Procyanidin A2 Ficusin A SW157765 Fasentin Dodoviscin I GLUT inhibitor-1 GT 949

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BAY-876 1799753-84-6 Metabolism transporter Inhibitor metabolism ovarian glycolytic cancer Glucose transporter BAY 876 glucose inhibit BAY876 orally GLUT inhibitor

 

TargetMol