Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BAY-876 is an orally active and selective inhibitor of glucose transporter 1 (GLUT1, IC50= 2 nM). BAY-876 exhibits <130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 also inhibits glycolytic metabolism and ovarian cancer growth.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 56.00 | |
2 mg | In stock | $ 79.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 148.00 | |
25 mg | In stock | $ 273.00 | |
50 mg | In stock | $ 449.00 | |
100 mg | In stock | $ 659.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 108.00 |
Description | BAY-876 is an orally active and selective inhibitor of glucose transporter 1 (GLUT1, IC50= 2 nM). BAY-876 exhibits >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 also inhibits glycolytic metabolism and ovarian cancer growth. |
Targets&IC50 | GLUT1:0.002 μM |
In vitro | BAY-876 is a highly-selective GLUT1 inhibitor with selectivity over GLUT2, 3, and 4 of 4700-, 800-, and 135-fold, respectively[1]. |
In vivo | BAY-876 displays low clearance also in?vivo in rat and in dog. The volume of distribution in steady state (Vss) is moderate in both species. Terminal half life is intermediate in rat (2.5 h) and long in dog (22 h) due to the very low clearance. The oral bioavailability (F%) is 85% and 79% in rat and dog, respectively. Preliminary in?vivo PK studies of BAY-876 demonstrate that a good oral bioavailability and long terminal half-life is attainable making it an excellent chemical probe to further evaluate the hypothesis of cancer treatment with a very selective GLUT1 inhibitor[1]. |
Molecular Weight | 496.42 |
Formula | C24H16F4N6O2 |
CAS No. | 1799753-84-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 3 mg/mL (6.04 mM)
DMSO: 92 mg/mL (185.4 mM)
You can also refer to dose conversion for different animals. More
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BAY-876 1799753-84-6 Metabolism transporter Inhibitor metabolism ovarian glycolytic cancer Glucose transporter BAY 876 glucose inhibit BAY876 orally GLUT inhibitor