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BH3I-1
🥰Excellent
Catalog No. T1493Cas No. 300817-68-9
Alias BHI1
BH3I-1 (BHI1) is a Bcl-2 antagonist.
BH3I-1
🥰Excellent
Purity: 98.2%
Catalog No. T1493Alias BHI1Cas No. 300817-68-9
BH3I-1 (BHI1) is a Bcl-2 antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 28 € | In Stock | |
| 2 mg | 37 € | In Stock | |
| 5 mg | 59 € | In Stock | |
| 10 mg | 93 € | In Stock | |
| 25 mg | 187 € | In Stock | |
| 50 mg | 319 € | In Stock | |
| 100 mg | 534 € | In Stock |
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Purity:98.2%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BH3I-1 (BHI1) is a Bcl-2 antagonist. |
| Targets&IC50 | MDM2-p53:5.3 μM(Kd), BH3-BCL XL:2.4 μM(Ki) |
| In vitro | BH3I-1 inhibits Bcl-xL heterodimerization in vitro. It also induces cytochrome c release[1]. BH3I-1, while inhibiting its reported target Bcl-2/Bim and Bcl-xL/Bim, shows significant inhibition of both the p53/hDM2 and p300/Hif-1a interactions[2]. |
| Cell Research | Cells (5×104 cells per well) are seeded into white 96-well plates (Costar) and treated with various concentrations of the compounds for 48 h. For zVAD-FMK protection experiments, cells are preincubated with 100 μM zVAD-FMK for 1 h before the addition of chemicals. Cell viability is determined with an MTS assay. For PI staining experiments, cells are grown in 24-well plates and then incubated with 2 μg ml/L PI. Cell death is determined by FACS analysis.(Only for Reference) |
| Alias | BHI1 |
| Molecular Weight | 400.31 |
| Formula | C15H14BrNO3S2 |
| Cas No. | 300817-68-9 |
| Smiles | CC(C)C(N1C(=S)S\C(=C\c2ccc(Br)cc2)C1=O)C(O)=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 60 mg/mL (149.9 mM) Ethanol: 11 mg/mL (27.5 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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