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BH3I-1

Catalog No. T1493Cas No. 300817-68-9
Alias BHI1

BH3I-1 (BHI1) is a Bcl-2 antagonist.

BH3I-1

BH3I-1

Purity: 98.2%
Catalog No. T1493Alias BHI1Cas No. 300817-68-9
BH3I-1 (BHI1) is a Bcl-2 antagonist.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
2 mg$39In Stock
5 mg$63In Stock
10 mg$98In Stock
25 mg$197In Stock
50 mg$336In Stock
100 mg$563In Stock
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Purity:98.2%
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Product Introduction

Bioactivity
Description
BH3I-1 (BHI1) is a Bcl-2 antagonist.
Targets&IC50
BH3-BCL XL:2.4 μM(Ki), MDM2-p53:5.3 μM(Kd)
In vitro
BH3I-1 inhibits Bcl-xL heterodimerization in vitro. It also induces cytochrome c release[1]. BH3I-1, while inhibiting its reported target Bcl-2/Bim and Bcl-xL/Bim, shows significant inhibition of both the p53/hDM2 and p300/Hif-1a interactions[2].
Cell Research
Cells (5×104 cells per well) are seeded into white 96-well plates (Costar) and treated with various concentrations of the compounds for 48 h. For zVAD-FMK protection experiments, cells are preincubated with 100 μM zVAD-FMK for 1 h before the addition of chemicals. Cell viability is determined with an MTS assay. For PI staining experiments, cells are grown in 24-well plates and then incubated with 2 μg ml/L PI. Cell death is determined by FACS analysis.(Only for Reference)
AliasBHI1
Chemical Properties
Molecular Weight400.31
FormulaC15H14BrNO3S2
Cas No.300817-68-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 60 mg/mL (149.9 mM)
Ethanol: 11 mg/mL (27.5 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.4981 mL12.4903 mL24.9806 mL124.9032 mL
5 mM0.4996 mL2.4981 mL4.9961 mL24.9806 mL
10 mM0.2498 mL1.2490 mL2.4981 mL12.4903 mL
20 mM0.1249 mL0.6245 mL1.2490 mL6.2452 mL
DMSO
1mg5mg10mg50mg
50 mM0.0500 mL0.2498 mL0.4996 mL2.4981 mL
100 mM0.0250 mL0.1249 mL0.2498 mL1.2490 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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