Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BH3I-1 (BHI1) is a Bcl-2 antagonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
2 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 63.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 336.00 | |
100 mg | In stock | $ 563.00 |
Description | BH3I-1 (BHI1) is a Bcl-2 antagonist. |
Targets&IC50 | BH3-Bcl-xL interaction:2.4 μM(Ki), p53/MDM2:5.3 μM(Kd) |
In vitro | BH3I-1 inhibits Bcl-xL heterodimerization in vitro. It also induces cytochrome c release[1]. BH3I-1, while inhibiting its reported target Bcl-2/Bim and Bcl-xL/Bim, shows significant inhibition of both the p53/hDM2 and p300/Hif-1a interactions[2]. |
Cell Research | Cells (5×104 cells per well) are seeded into white 96-well plates (Costar) and treated with various concentrations of the compounds for 48 h. For zVAD-FMK protection experiments, cells are preincubated with 100 μM zVAD-FMK for 1 h before the addition of chemicals. Cell viability is determined with an MTS assay. For PI staining experiments, cells are grown in 24-well plates and then incubated with 2 μg ml/L PI. Cell death is determined by FACS analysis.(Only for Reference) |
Synonyms | BHI1 |
Molecular Weight | 400.31 |
Formula | C15H14BrNO3S2 |
CAS No. | 300817-68-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 60 mg/mL (149.9 mM)
Ethanol: 11 mg/mL (27.5 mM)
You can also refer to dose conversion for different animals. More
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BH3I-1 300817-68-9 Apoptosis Ubiquitination E1/E2/E3 Enzyme BCL MDM-2/p53 BH3I 1 BHI-1 Inhibitor Ubiquitin ligase E3 ligating enzyme Ubiquitin conjugating enzyme BH3I1 E2 conjugating enzyme Bcl-2 Family BHI1 E1 activating enzyme inhibit BH 3I1 BHI 1 Ubiquitin activating enzyme BH-3I-1 inhibitor