Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase. BI-4020 exhibits activity agains the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM) and EGFR wt (IC50=190 nM). BI-4020 exhibits high kinome selectivity and good DMPK properties.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 288.00 | |
5 mg | In stock | $ 697.00 | |
10 mg | In stock | $ 996.00 | |
25 mg | In stock | $ 1,490.00 | |
50 mg | In stock | $ 1,990.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 851.00 |
Description | BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase. BI-4020 exhibits activity agains the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM) and EGFR wt (IC50=190 nM). BI-4020 exhibits high kinome selectivity and good DMPK properties. |
Targets&IC50 | EGFRWT:190 nM, EGFRdel19 T790M C797S:0.2 nM, EGFRdel19:1 nM |
In vitro | BI-4020 inhibits p-EGFR del19 T790M C797S ( IC50: 0.6 nM). BI-4020 inhibits not only the triple mutant EGFR (del19/T790M/C797S) variant (IC50=0.2 nM in BaF3 cell lines) but also the double mutant EGFR (del19/T790M) and primary mutant EGFR del19 (IC50: 1 nM). BI-4020 also shows activity against EGFR wt (IC50: 190 nM). BI-4020 shows high kinome selectivity and good DMPK properties. |
In vivo | In the human PC-9 (EGFR del19/T790M/C797S) triple mutant NSCLC xenograft model in mice, BI-4020 leads to tumor regressions. |
Molecular Weight | 542.68 |
Formula | C30H38N8O2 |
CAS No. | 2664214-60-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 240 mg/mL (442.25 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BI-4020 2664214-60-0 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HER1 inhibit BI4020 BI 4020 Epidermal growth factor receptor ErbB-1 Inhibitor inhibitor