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BMS-794833

Catalog No. T2419 CAS 1174046-72-0

BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2; a prodrug of BMS-817378.

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BMS-794833, CAS 1174046-72-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 35.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 90.00
10 mg	In stock	$ 153.00
25 mg	In stock	$ 312.00
50 mg	In stock	$ 566.00
100 mg	In stock	$ 812.00
1 mL * 10 mM (in DMSO)	In stock	$ 96.00

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Purity: 99.79%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2; a prodrug of BMS-817378.
Targets&IC50	MET:1.7 nM, VEGFR2:15 nM
In vitro	At a dosage of 25 mg/kg, BMS798433 exhibited complete inhibition of tumor growth in the U87 glioblastoma model. In the GTL-16 human gastric tumor xenograft model, treatment with BMS798433 for 14 days resulted in a Tumor Growth Inhibition (TGI) rate of over 50% within at least one tumor doubling time, with no significant toxicity observed during the period.
In vivo	BMS794833 inhibits the activation of the Met receptor in the gastric cancer cell line GTL-16, with an IC50 of 39 nM.
Kinase Assay	Met kinase assay: BMS798433 is dissolved in DMSO and diluted by water before use. The reaction solution contains baculovirus expressed GST-Met kinase, 20 mM Tris-HCl (pH 7.4), 1 mM MnCl2, 1 mM DTT, 0.1 mg BSA, 0.1 mg polyGlu4/tyr, 1 μM ATP and 0.2μCi γ–ATP. Reactions are incubated at 30 °C for 1 hour and stopped by 8% TCA. TCA precipitates are collected onto GF/C plates using a universal harvester and the filters are quantitated using liquid scintillation counter.
Cell Research	GTL-16 cells are seeded into 96 well plates and incubated for 24 hours. BMS798433 is dissolved in DMSO at 10 mM and diluted with culture medium before use. Then BMS798433 is added to the cells for 72 hours. After that, MTS assay is used to measure the IC50.(Only for Reference)

Molecular Weight	468.84
Formula	C23H15ClF2N4O3
CAS No.	1174046-72-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 87 mg/mL (185.6 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. WO2009094417A1

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Inhibitor Library Anti-Breast Cancer Compound Library ReFRAME Related Library Cytokine Inhibitor Library Anti-Lung Cancer Compound Library Preclinical Compound Library Reprogramming Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-794833 1174046-72-0 Angiogenesis Tyrosine Kinase/Adaptors VEGFR c-Met/HGFR BMS794833 Inhibitor inhibit Vascular endothelial growth factor receptor BMS 794833 inhibitor

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