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BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $29 | In Stock | |
5 mg | $46 | In Stock | |
10 mg | $64 | In Stock | |
25 mg | $98 | In Stock | |
50 mg | $148 | In Stock | |
100 mg | $218 | In Stock | |
1 mL x 10 mM (in DMSO) | $55 | In Stock |
Description | BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. |
Targets&IC50 | RSK1:1.5 μM, RSK2:2.4 μM, PKG1α:6.5 μM, DRAK1:2.8 μM, SGK:13.8 μM, RSK3:1.2 μM, FLT3:3.5 μM, CDK5-p35:6.5 μM, Pim1:3.7 μM |
In vitro | BRD7389 (1 μM) almost completely blocked Carbachol (1 mM)-stimulated cell proliferation, but has little effect on the basal level of proliferation[1]. BRD7389 (0.425, 0.85, 1.7, 3.4, 6.8 μM) induces insulin expression in mouse α-cells and induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM. BRD7389 increases β-cell-specific gene expression in primary human islet cells. BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line[2]. |
Molecular Weight | 366.41 |
Formula | C24H18N2O2 |
Cas No. | 376382-11-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 20 mg/mL (54.58 mM), Sonication and heating to 60℃ are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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