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BRD7389

Catalog No. T14779 CAS 376382-11-5

BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.

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BRD7389, CAS 376382-11-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 77.00
10 mg	In stock	$ 106.00
25 mg	In stock	$ 169.00
50 mg	In stock	$ 247.00
100 mg	In stock	$ 364.00
1 mL * 10 mM (in DMSO)	In stock	$ 91.00

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Purity: 99.17%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
Targets&IC50	FLT3:3.5 μM, RSK3:1.2 μM, CDK5-p35:6.5 μM, Pim1:3.7 μM, DRAK1:2.8 μM, PKG1α:6.5 μM, SGK:13.8 μM, RSK2:2.4 μM, RSK1:1.5 μM
In vitro	BRD7389 (1 μM) almost completely blocked Carbachol (1 mM)-stimulated cell proliferation, but has little effect on the basal level of proliferation[1]. BRD7389 (0.425, 0.85, 1.7, 3.4, 6.8 μM) induces insulin expression in mouse α-cells and induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM. BRD7389 increases β-cell-specific gene expression in primary human islet cells. BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line[2].

Molecular Weight	366.41
Formula	C24H18N2O2
CAS No.	376382-11-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (54.58 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Park YS, et al. EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. Mol Cell Biochem. 2012 Nov;370(1-2):191-8. 2. Fomina-Yadlin D, et al. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15099-104.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Compound Library Antidepressant Compound Library Anti-Liver Cancer Compound Library Anti-Lung Cancer Compound Library Metabolism Compound Library Glycolysis Compound Library Neuronal Differentiation Compound Library

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Related compounds with same targets

SI-113 EMD638683 AT13148 EMD638683 R-Form CKI-7 PROTAC SGK3 degrader-1 GSK 650394 URMC-099

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BRD7389 376382-11-5 Angiogenesis Apoptosis Cell Cycle/Checkpoint Chromatin/Epigenetic JAK/STAT signaling MAPK Metabolism PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors CDK DAPK S6 Kinase FLT Pim SGK cancer S6K Inhibitor colon BRD 7389 inhibit RSK islets diabetes pancreatic SNU-407 BRD-7389 Ribosomal S6 Kinase (RSK) inhibitor

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