Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 96.00 | |
10 mg | In stock | $ 142.00 | |
25 mg | In stock | $ 238.00 | |
50 mg | In stock | $ 353.00 | |
100 mg | In stock | $ 526.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms. |
In vitro | BVT948 exhibits dose-dependent inhibition of TPA-induced MMP-9 up-regulation, without affecting MAPK phosphorylation caused by TPA. It reduces TPA-induced cell invasion by 50%. Interestingly, BVT948 does not significantly alter cell viability in MCF-7 cells at concentrations of 0.5, 1, or 5 μM over 24 hours. Furthermore, BVT948 is a potent inhibitor of protein tyrosine phosphatases (PTP) and P450 activities, demonstrating its ability to selectively suppress H4 lysine 20 (H4K20me1) methylation at doses below 5 μM within 24 hours. Additionally, it enhances the insulin signal's strength without affecting its duration and induces cell-cycle-arrest phenotypes reminiscent of those observed with SETD8 knockdown via RNAi. BVT948 also effectively inhibits TPA-induced NF-κB binding activity but not AP-1 binding activity, showcasing its selective inhibitory properties on specific molecular targets. |
In vivo | Compare with vehicle-treated controls, BVT948 (BVT.948, 3 μmol/kg) significantly enhances glucose clearance from the blood stream in response to insulin[1]. |
Molecular Weight | 241.24 |
Formula | C14H11NO3 |
CAS No. | 39674-97-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (414.52 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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BVT948 39674-97-0 Chromatin/Epigenetic Metabolism P450 Phosphatase Histone Methyltransferase Cytochrome P450 Inhibitor BVT 948 BVT-948 CYPs inhibit inhibitor