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Bucillamine

Catalog No. T21334 CAS 65002-17-7

Synonyms: DE-019, Thiobutarit, Tiobutarit, SA96, DE 019, DE019

Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF. Bucillamine is an orally active sulfhydryl donor and antioxidant with antirheumatic and antiangiogenic properties. Bucillamine can be used for studies about choroidal neovascularization and rheumatoid arthritis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Bucillamine, CAS 65002-17-7

Pack Size	Availability	Price/USD
10 mg	In stock	$ 34.00
25 mg	In stock	$ 55.00
50 mg	In stock	$ 93.00
100 mg	In stock	$ 155.00
500 mg	In stock	$ 389.00
1 mL * 10 mM (in DMSO)	In stock	$ 31.00

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Biological Description

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Storage & Solubility Information

Description	Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF. Bucillamine is an orally active sulfhydryl donor and antioxidant with antirheumatic and antiangiogenic properties. Bucillamine can be used for studies about choroidal neovascularization and rheumatoid arthritis.
In vivo	In rats subjected to liver transplants, Bucillamine significantly enhances survival and protected against hepatic injury[2]. Subconjunctival injection of Bucillamine significantly reduces the leakage and size of experimental CNV in rats[3].

Synonyms	DE-019, Thiobutarit, Tiobutarit, SA96, DE 019, DE019
Molecular Weight	223.31
Formula	C7H13NO3S2
CAS No.	65002-17-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (111.95 mM)

References and Literature

1. Kim SJ, et al. Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes. Exp Mol Med. 2015 Feb 20;47:e142. 2. Amersi F, et al. Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8915-20. 3. Yanagi Y, et al. Subconjunctival administration of bucillamine suppresses choroidal neovascularization in rat. Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3495-9. 4. Manabe S, et al. Bucillamine-induced membranous nephropathy with crescent formation in a patient with rheumatoid arthritis: case report and literature review. Case Rep Nephrol Dial. 2014 Oct 29;5(1):30-8.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library FDA-Approved Kinase Inhibitor Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Human Metabolite Library Orally Active Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bucillamine 65002-17-7 Angiogenesis oxidation-reduction Tyrosine Kinase/Adaptors VEGFR Antioxidant rheumatoid arthritis DE-019 Thiobutarit Ischemia/reperfusion Tiobutarit antioxidant antirheumatic inhibit Inhibitor SA96 SA-96 DE 019 antiangiogenic SA 96 Vascular endothelial growth factor receptor choroidal neovascularization DE019 inhibitor

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