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C 87

Catalog No. T14848 CAS 332420-90-3

C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

C 87, CAS 332420-90-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 39.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 198.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 71.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.
Targets&IC50	TNF-α induced cytotoxicity:8.73 μM
In vitro	C 87 reduces the activity of c-Jun N-terminal kinase (JNK) in L929 cells. C 87 prevents the degradation of IκBα in cells treated with TNF-α and potently blocks multiple signaling transduction pathways and downstream target gene activation triggered by TNF-α. C 87 exhibits good solubility and consistent dose-dependent functions in vitro. C 87 completely blocks the TNFα-induced activation of caspase-3 and caspase-8[1].
In vivo	In mice, the level of alanine transaminase and aspartate transaminase is consistently reduced. C 87 markedly reduces injuries to the liver and improves animal survival. C 87 injection delays the incidence of death and increases the survival rate by two fo

Molecular Weight	502.93
Formula	C24H15ClN6O3S
CAS No.	332420-90-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (9.94 mM), Sonification is recommended.

References and Literature

1. Ma L, et al. A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J Biol Chem. 2014 May 2;289(18):12457-66.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Pyroptosis Compound Library NF-κB Signaling Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

C 87 332420-90-3 Apoptosis Others TNF TNF Receptor inhibit C-87 Tumor Necrosis Factor Receptor Inhibitor TNFR C87 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.