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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $38 | In Stock | |
5 mg | $88 | In Stock | |
10 mg | $143 | In Stock | |
25 mg | $295 | In Stock | |
50 mg | $513 | In Stock | |
100 mg | $818 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | CFI-400945 is an potent, selective and orally active inhibitor of polo-like kinase 4(PLK4; Ki value of 0.26 nM). |
Targets&IC50 | PLK4:0.26 nM(ki) |
In vitro | CFI-400945, a potent and selective PLK4 inhibitor.?Cancer cells treated with CFI-400945 exhibit effects consistent with PLK4 kinase inhibition, including dysregulated centriole duplication, mitotic defects, and cell death[1]. |
In vivo | Oral administration of CFI-400945 to mice bearing human cancer xenografts results in the significant inhibition of tumor growth at doses that are well tolerated[1]. |
Molecular Weight | 534.65 |
Formula | C33H34N4O3 |
Cas No. | 1338806-73-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 100 mg/mL (187.04 mM) H2O: Insoluble DMSO: 100 mg/mL (187.04 mM), Heating to 50℃ is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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