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CMP8

Catalog No. T14987   CAS 851107-28-3

CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively.

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CMP8 Chemical Structure
CMP8, CAS 851107-28-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 253.00
5 mg In stock $ 520.00
10 mg In stock $ 743.00
25 mg In stock $ 1,150.00
50 mg In stock $ 1,550.00
100 mg In stock $ 1,980.00
1 mL * 10 mM (in DMSO) In stock $ 652.00
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Purity: 99.38%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively.
Targets&IC50 MGRERα:41 nM, MGERα:29 nM, hERα:1100 nM, hERβ:2200 nM
In vivo CMP8 is dosed in male Balb-c mice (4 mg/kg, ip). In mammalian cells, the plasma concentration after 4 h is 1.5-fold its EC50. It has a Cmax of 0.5 μM after 30 min.[1][2]
Molecular Weight 528.08
Formula C33H34ClNO3
CAS No. 851107-28-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (94.68 mM)

TargetMolReferences and Literature

1. Miyazaki Y, et al. Destabilizing domains derived from the human estrogen receptor. J Am Chem Soc. 2012 Mar 7;134(9):3942-5. 2. Kinzel O, et al. A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies. J Med Chem. 2006 Sep 7;49(18):5404-7.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Ovarian Cancer Compound Library Anti-Cancer Compound Library Endocrinology-Hormone Compound Library Nuclear Receptor Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Bioactive Compound Library

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Keywords

CMP8 851107-28-3 Endocrinology/Hormones Estrogen/progestogen Receptor Estrogen Receptor/ERR inhibit CMP 8 Inhibitor CMP-8 inhibitor

 

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