Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 253.00 | |
5 mg | In stock | $ 520.00 | |
10 mg | In stock | $ 743.00 | |
25 mg | In stock | $ 1,150.00 | |
50 mg | In stock | $ 1,550.00 | |
100 mg | In stock | $ 1,980.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 652.00 |
Description | CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively. |
Targets&IC50 | MGRERα:41 nM, MGERα:29 nM, hERα:1100 nM, hERβ:2200 nM |
In vivo | CMP8 is dosed in male Balb-c mice (4 mg/kg, ip). In mammalian cells, the plasma concentration after 4 h is 1.5-fold its EC50. It has a Cmax of 0.5 μM after 30 min.[1][2] |
Molecular Weight | 528.08 |
Formula | C33H34ClNO3 |
CAS No. | 851107-28-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (94.68 mM)
You can also refer to dose conversion for different animals. More
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CMP8 851107-28-3 Endocrinology/Hormones Estrogen/progestogen Receptor Estrogen Receptor/ERR inhibit CMP 8 Inhibitor CMP-8 inhibitor