Powder: -20°C for 3 years
In solvent: -80°C for 2 years
CPI-360 is a potent, selective, and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
Description | CPI-360 is a potent, selective, and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases. |
Targets&IC50 | EZH1:102.3 nM |
In vitro | In KARPAS-422 cells, CPI-360 potently reduces global H3K27me3 and H3K27me2 levels with EC50 of 56 nM and 65 nM, respectively. CPI-360 also causes time-dependent transcriptional changes, and affects the viability of Y641N mutant EZH2-containing KARPAS-422 cells. In addition, CPI-360 gradually arrests KARPAS-422 cells in the G1 cell cycle stage followed by the induction of apoptosis. [1] |
In vivo | In mice bearing KARPAS-422 xenografts, CPI-360 (200 mg/kg, s.c.) reduces tumor growth by 44%. [1] |
Synonyms | CPI360, CPI 360 |
Molecular Weight | 437.54 |
Formula | C25H31N3O4 |
CAS No. | 1802175-06-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 16 mg/mL (36.6 mM)
H2O: <1 mg/mL
Ethanol: 15 mg/mL (34.3 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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CPI-360 1802175-06-9 表观遗传 凋亡 Apoptosis Histone Methyltransferase CPI360 CPI 360 Inhibitor inhibitor inhibit