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CPI-360

Catalog No. T6810 CAS 1802175-06-9

Synonyms: Synonym 2, CPI 360, CPI360

CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CPI-360, CAS 1802175-06-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 76.00
5 mg	In stock	$ 175.00
10 mg	In stock	$ 285.00
25 mg	In stock	$ 478.00
50 mg	In stock	$ 687.00
100 mg	In stock	$ 998.00

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Purity: 99.52%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.
Targets&IC50	EZH1:102.3 nM
In vitro	In KARPAS-422 cells, CPI-360 potently reduces global H3K27me3 and H3K27me2 levels with EC50 of 56 nM and 65 nM, respectively. CPI-360 also causes time-dependent transcriptional changes, and affects the viability of Y641N mutant EZH2-containing KARPAS-422 cells. In addition, CPI-360 gradually arrests KARPAS-422 cells in the G1 cell cycle stage followed by the induction of apoptosis. [1]
In vivo	In mice bearing KARPAS-422 xenografts, CPI-360 (200 mg/kg, s.c.) reduces tumor growth by 44%. [1]

Synonyms	Synonym 2, CPI 360, CPI360
Molecular Weight	437.53
Formula	C25H31N3O4
CAS No.	1802175-06-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (51.4 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMF: 9.0 mg/mL (20.6 mM)

Ethanol: 27.0 mg/mL (61.7 mM)

References and Literature

1. Vatolin S, et al. Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma. Cancer Res. 2016 Jun 1;76(11):3340-50. 2. Felder ChB, et al. Ultrasonic atomization and subsequent polymer desolvation for peptide and protein microencapsulation into biodegradable polyesters. J Microencapsul. 2003;20(5):553-567. 3. Arora S, et al. EZH2 inhibitors are broadly efficacious in multiple myeloma as single agent and in combination with standard of care therapeutics. 2016. 4. Lang S, et al. Transport and metabolic pathway of thymocartin (TP4) in excised bovine nasal mucosa. J Pharm Pharmacol. 1996;48(11):1190-1196.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Histone Modification Compound Library Anti-Cancer Compound Library

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Related compounds with same targets

GS-444217 Piperlongumine GPNA hydrochloride ZZW-115 hydrochloride PTC-028 Dextran sulfate sodium salt (MW 4500-5500) Ripretinib ROS-generating agent 1

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CPI-360 1802175-06-9 Apoptosis Chromatin/Epigenetic Histone Methyltransferase Synonym 2 CPI 360 CPI360 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.