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CU-CPT22

Catalog No. T15020 CAS 1416324-85-0

CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 (Ki: 0.41 μM).

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CU-CPT22, CAS 1416324-85-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
2 mg	In stock	$ 64.00
5 mg	In stock	$ 101.00
10 mg	In stock	$ 171.00
25 mg	In stock	$ 329.00
50 mg	In stock	$ 493.00
100 mg	In stock	$ 718.00
1 mL * 10 mM (in DMSO)	In stock	$ 116.00

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Purity: 99.3%

Biological Description

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Storage & Solubility Information

Description	CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 (Ki: 0.41 μM).
Targets&IC50	TLR2/1:(ki)0.41 μM
In vitro	A novel compound (CU-CPT22) that can compete with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with high inhibitory activity and specificity.CU-CPT22 is a toll-like inhibitor of receptor 1 and 2 (TLR1/2) ( IC50: 0.58±0.09 μM).?CU-CPT22 is found to have no significant cytotoxicity at various concentrations up to 100 μM in RAW 264.7 cells.?It is showed that CU-CPT22 is able to compete with Pam3CSK4 for binding to TLR1/2 (Ki: 0.41±0.07 μM).?Which is consistent with its potency observed in the whole cell assay.?Increasing the concentration of CU-CPT22 to 6 μM decreases the anisotropy to background levels.?It is found that CU-CPT22 inhibits TLR1/2 signaling without affecting other TLRs, showing it is highly selective in intact cells.??The result shows that CU-CPT22 can inhibit about 60% of TNF-αand 95% of IL-1β at 8 μM[1].

Molecular Weight	362.37
Formula	C19H22O7
CAS No.	1416324-85-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (344.95 mM)

References and Literature

1. Cheng K, et al. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem Int Ed Engl. 2012 Dec 3;51(49):12246-9.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Highly Selective Inhibitor Library Bioactive Compounds Library Max Pyroptosis Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library HIF-1 Signaling Pathway Compound Library Immuno-Oncology Compound Library

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Keywords

CU-CPT22 1416324-85-0 Immunology/Inflammation TLR inhibit CU CPT22 Inhibitor Toll-like Receptor (TLR) CUCPT22 CU-CPT-22 inhibitor

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