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Cepharanthine

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Purity:99.95%

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COA HPLC HNMR

Cepharanthine

Catalog No. T0131Cas No. 481-49-2

Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and inhibits cytokine production.

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Pack Size	Price	Availability
50 mg	$45	In Stock
100 mg	$58	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and inhibits cytokine production.
In vitro	In a xenograft model using SAOS2 cells in athymic mice, daily treatment with Cepharanthine (20 mg/kg) significantly reduced tumor volume and weight.
In vivo	In SaOS2 cells, Cepharanthine (2.5–20 μmol/L) inhibits cell growth in a concentration- and time-dependent manner. At concentrations of 5–10 μmol/L, Cepharanthine markedly suppresses the expression of STAT3 target genes, including the anti-apoptotic gene Bcl-xL and cell cycle regulators c-Myc and cyclin D1. At 10 μmol/L, Cepharanthine induces a cell cycle arrest at the G1 phase and promotes apoptosis in SaOS2 cells. Furthermore, Cepharanthine (10–15 μmol/L) significantly reduces STAT3 expression in SAOS2 cells.
Alias	NSC-623442

Chemical Properties

Molecular Weight	606.71
Formula	C37H38N2O6
Cas No.	481-49-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (82.41 mM)

5% DMSO+95% Saline: 4.65 mg/mL (7.66 mM, precipitation)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO/5% DMSO+95% Saline

	1mg	5mg	10mg	50mg
1 mM	1.6482 mL	8.2412 mL	16.4823 mL	82.4117 mL
5 mM	0.3296 mL	1.6482 mL	3.2965 mL	16.4823 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1648 mL	0.8241 mL	1.6482 mL	8.2412 mL
20 mM	0.0824 mL	0.4121 mL	0.8241 mL	4.1206 mL
50 mM	0.0330 mL	0.1648 mL	0.3296 mL	1.6482 mL
100 mM	0.0165 mL	0.0824 mL	0.1648 mL	0.8241 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify

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