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Chlorambucil

Catalog No. T0975 CAS 305-03-3

Synonyms: CB-1348, Chloroambucil, WR-139013

Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.

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Chlorambucil, CAS 305-03-3

Pack Size	Availability	Price/USD
25 mg	In stock	$ 50.00
50 mg	In stock	$ 63.00
100 mg	In stock	$ 101.00
200 mg	In stock	$ 144.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 99.58%

Purity: 98.45%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	CB-1348, Chloroambucil, WR-139013
Molecular Weight	304.21
Formula	C14H19Cl2NO2
CAS No.	305-03-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 56 mg/mL (184.1 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 56 mg/mL (184.1 mM)

References and Literature

1. Kashiwazaki G, et al. Bioorg Med Chem. 2010 Apr 15;18(8):2887-93.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library ReFRAME Related Library DNA Damage & Repair Compound Library Anti-Lung Cancer Compound Library Bioactive Compounds Library Max FDA-Approved Drug Library

Related Products

Related compounds with same targets

N-Nitroso-N-methylurea Cyclophosphamide PK11000 Oxaliplatin Bendamustine Carmustine Altretamine Semustine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Chlorambucil 305-03-3 DNA Damage/DNA Repair DNA Alkylation DNA Alkylator/Crosslinker CB-1348 Chloroambucil histones mutations WR 139013 inhibit malignancies WR139013 p53 alkylator proteins Inhibitor DNA WR-139013 CB1348 nuclear CB 1348 inhibitor

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