Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cilastatin (MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 30.00 | |
10 mg | In stock | $ 37.00 | |
25 mg | In stock | $ 57.00 | |
50 mg | In stock | $ 81.00 | |
100 mg | In stock | $ 126.00 | |
200 mg | In stock | $ 198.00 | |
500 mg | In stock | $ 343.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Cilastatin (MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4. |
Targets&IC50 | Metallob-lactamase enzyme CphA (bacterial):178 μM (IC50), Renal dehydropeptidase I:0.1 μM (IC50) |
Synonyms | MK0791 |
Molecular Weight | 358.45 |
Formula | C16H26N2O5S |
CAS No. | 82009-34-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (125.54 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Cilastatin 82009-34-5 Microbiology/Virology Proteases/Proteasome Ubiquitination Antibacterial Antibiotic Proteasome CphA metallob-lactamase MK-0791 dehydropeptidase Bacterial MK 0791 zinc antibacterial Renal adjunct Inhibitor peptidase MK0791 inhibit inhibitor