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Crocin II

Catalog No. T3779 CAS 55750-84-0

Synonyms: Crocin 2, Crocetin gentiobiosylglucosyl ester, Tricrocin, Crocin B

Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expression of iNOS and caspase-3. Crocin II can ameliorate CCl4-induced liver injury via inhibition of inflammatory cytokines, caspase3 and oxidative stress along with modulation of liver metabolizing enzymes favoring elimination of CCl4 toxic metabolite. Crocin II has antihyperlipidemic effect, may be due to the inhibition of pancreatic lipase and crocin, and its metabolite, Crocin II , can improve hyperlipidemia. Crocin has antidepressant effects by increasing CREB, BDNF and VGF levels in hippocampus.

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Crocin II, CAS 55750-84-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 96.00
10 mg	In stock	$ 165.00
25 mg	In stock	$ 319.00
50 mg	In stock	$ 479.00
100 mg	In stock	$ 688.00
500 mg	In stock	$ 1,420.00

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Purity: 99.19%

Purity: 98.22%

Purity: 98%

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Chemical Properties

Storage & Solubility Information

Description	Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expression of iNOS and caspase-3. Crocin II can ameliorate CCl4-induced liver injury via inhibition of inflammatory cytokines, caspase3 and oxidative stress along with modulation of liver metabolizing enzymes favoring elimination of CCl4 toxic metabolite. Crocin II has antihyperlipidemic effect, may be due to the inhibition of pancreatic lipase and crocin, and its metabolite, Crocin II , can improve hyperlipidemia. Crocin has antidepressant effects by increasing CREB, BDNF and VGF levels in hippocampus.
Targets&IC50	NO production:31.3 μM (IC50)
Source	Natural Products > Iridaceae > Crocus

Synonyms	Crocin 2, Crocetin gentiobiosylglucosyl ester, Tricrocin, Crocin B
Molecular Weight	814.82
Formula	C38H54O19
CAS No.	55750-84-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 122.7 mM

References and Literature

1. Lee IA,et al. Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin. Biol Pharm Bull. 2005 Nov;28(11):2106-10.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Protease Inhibitor Library Antioxidant Compound Library Natural Product Library Human Metabolite Library Anti-Tumor Natural Product Library Apoptosis Compound Library Oxidation-Reduction Compound Library Immunology/Inflammation Compound Library

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Keywords

Crocin II 55750-84-0 Apoptosis Immunology/Inflammation Neuroscience Proteases/Proteasome NO Synthase Caspase COX NOS Crocin 2 inhibit Cyclooxygenase Nitric oxide synthases Crocetin gentiobiosylglucosyl ester Inhibitor Tricrocin Crocin B inhibitor

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