Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 132.00 | |
2 mg | In stock | $ 196.00 | |
5 mg | In stock | $ 297.00 | |
10 mg | In stock | $ 443.00 | |
25 mg | In stock | $ 732.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,390.00 | |
500 mg | In stock | $ 2,790.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 329.00 |
Description | DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively). |
Targets&IC50 | PRMT1:37.1 μM, DNMT1:1.09 μM (kd), DNMT1:10.3 μM |
In vitro | DC-05 is a non-nucleoside DNMT1 inhibitor with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases.?DC-05 (1.25, 2.5, 5, and 10 μM) effectively inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC-05 displays poor potent activities against DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50: >200, >200, >150, >150, >150, >150, 37.1 μM) [1]. |
Molecular Weight | 383.49 |
Formula | C25H25N3O |
CAS No. | 890643-16-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (260.76 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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DC-05 890643-16-0 Chromatin/Epigenetic DNA Methyltransferase Histone Methyltransferase Inhibitor DC 05 DC05 DNMTs DNA MTases inhibit inhibitor