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By Target- Chk
- DNA Methyltransferase(1)
- Histone Methyltransferase(1)
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Results for "
dc05
" in TargetMol Product Catalog- Inhibitors & Agonists2
DC-05
T15080890643-16-0
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
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GDC0575 monohydrochloride
ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575
T274071196504-54-7
GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
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