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DC-05

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Purity:99.94%

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COA HPLC HNMR

DC-05

Catalog No. T15080Cas No. 890643-16-0

DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).

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Pack Size	Price	Availability
1 mg	$132	In Stock
2 mg	$196	In Stock
5 mg	$297	In Stock
10 mg	$443	In Stock
25 mg	$732	In Stock
50 mg	$987	In Stock
100 mg	$1,390	In Stock
500 mg	$2,790	In Stock
1 mL x 10 mM (in DMSO)	$329	In Stock

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Product Introduction

Bioactivity

Description	DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
Targets&IC50	DNMT1:1.09 μM （kd）, DNMT1:10.3 μM, PRMT1:37.1 μM
In vitro	DC-05 is a non-nucleoside DNMT1 inhibitor with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases.?DC-05 (1.25, 2.5, 5, and 10 μM) effectively inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC-05 displays poor potent activities against DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50: >200, >200, >150, >150, >150, >150, 37.1 μM) [1].

Chemical Properties

Molecular Weight	383.49
Formula	C25H25N3O
Cas No.	890643-16-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (260.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6076 mL	13.0381 mL	26.0763 mL	130.3815 mL
5 mM	0.5215 mL	2.6076 mL	5.2153 mL	26.0763 mL
10 mM	0.2608 mL	1.3038 mL	2.6076 mL	13.0381 mL
20 mM	0.1304 mL	0.6519 mL	1.3038 mL	6.5191 mL
50 mM	0.0522 mL	0.2608 mL	0.5215 mL	2.6076 mL
100 mM	0.0261 mL	0.1304 mL	0.2608 mL	1.3038 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc