Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 165.00 | |
25 mg | In stock | $ 315.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse. |
Targets&IC50 | TLR7:4.6 nM (EC50, Mice), TLR7:7.2 nM (EC50, Human) |
In vitro | To assess the specificity of DSR-6434 toward TLR7, an NF-κB-driven reporter assay is performed in HEK293 cells engineered to express either hTLR7, TLR8 or TLR9. In this assay, successful binding of DSR-6434 to the specific receptor leads to NF-κB activation. DSR-6434 is capable of stimulating reporter gene activity only in HEK293 cells expressing hTLR7 and not in HEK293 cells expressing the structurally similar hTLR8 or hTLR9[1]. |
In vivo | In B6C3F1 mice, DSR-6434 (0.1-1 mg/kg; i.v.) significantly suppresses lung metastasis[1]. |
Molecular Weight | 400.48 |
Formula | C19H28N8O2 |
CAS No. | 1059070-10-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225mg/mL (561.8mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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DSR-6434 1059070-10-8 Immunology/Inflammation TLR DSR6434 DSR 6434 inhibitor inhibit