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Dabigatran ethyl ester hydrochloride

Catalog No. T10951 CAS 211914-50-0

Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a thrombin inhibitor.

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Dabigatran ethyl ester hydrochloride Chemical Structure

Dabigatran ethyl ester hydrochloride, CAS 211914-50-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 163.00
50 mg	In stock	$ 288.00
100 mg	In stock	$ 448.00
1 mL * 10 mM (in DMSO)	In stock	$ 56.00

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Purity: 98.7%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a thrombin inhibitor.
Targets&IC50	NQO2:0.8 μM
In vitro	Dabigatran (ethyl ester hydrochloride) has a Ki of 0.9 μM for NQO2 and an IC50 of 0.8 μM. The ethyl group (ethyl ester hydrochloride) of dabigatran significantly extends the interaction surface, especially with hydrophobic amino acids (such as Ile 128 and Met 154). Dabigatran ethyl ester has a higher affinity for thrombin and NQO2 than dabigatran [1]. Dabigatran is a highly selective, reversible and effective thrombin inhibitor, which can be taken orally as a prodrug dabigatran etexilate .
In vivo	Dabigatran (Ki = 4.5 nM) can selectively bind to human thrombin and reversibly achieve a strong and lasting anticoagulant effect.

Molecular Weight	536.03
Formula	C27H30ClN7O3
CAS No.	211914-50-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (93.28 mM)

H2O: 5 mg/mL (9.33 mM), Sonification is recommended.

References and Literature

1. Michaelis S, et al. Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2). J Med Chem. 2012 Apr 26;55(8):3934-44. 2. Eisert WG, et al. Dabigatran: an oral novel potent reversible nonpeptide inhibitor of thrombin. Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1885-9. 3. Hauel NH, et al. Structure-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem. 2002 Apr 25;45(9):1757-66.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Protease Inhibitor Library Bioactive Compounds Library Max Orally Active Compound Library

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Keywords

Dabigatran ethyl ester hydrochloride 211914-50-0 Others Proteases/Proteasome Thrombin Dabigatran ethyl ester inhibit Inhibitor Dabigatran ethyl ester Hydrochloride inhibitor

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