Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 128.00 | |
10 mg | In stock | $ 213.00 | |
25 mg | In stock | $ 359.00 | |
50 mg | In stock | $ 535.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 123.00 |
Description | Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells. |
Targets&IC50 | Trypsin:3.0 μM |
In vitro | demethylwedelolactone (DWEL) inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells.DWEL reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells.?Furthermore, DWEL suppressed the metastasis and lung colonization of the tumor cells in the nude mice.?DWEL derivatives exert anti-invasive growth effect on breast cancer cells. |
Source |
Molecular Weight | 300.22 |
Formula | C15H8O7 |
CAS No. | 6468-55-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (74.95 mM)
You can also refer to dose conversion for different animals. More
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Demethylwedelolactone 6468-55-9 Proteases/Proteasome Serine Protease Inhibitor inhibit Ser/Thr Protease Serine proteases Threonine proteases Serine endopeptidases inhibitor