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Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
5 mg | $128 | In Stock | |
10 mg | $213 | In Stock | |
25 mg | $359 | In Stock | |
50 mg | $535 | In Stock | |
1 mL x 10 mM (in DMSO) | $123 | In Stock |
Description | Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells. |
Targets&IC50 | Trypsin:3.0 μM |
In vitro | demethylwedelolactone (DWEL) inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells.DWEL reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells.?Furthermore, DWEL suppressed the metastasis and lung colonization of the tumor cells in the nude mice.?DWEL derivatives exert anti-invasive growth effect on breast cancer cells. |
Molecular Weight | 300.22 |
Formula | C15H8O7 |
Cas No. | 6468-55-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 22.5 mg/mL (74.95 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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