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Didanosine

Catalog No. T2578 CAS 69655-05-6

Synonyms: ddI, 2',3'-Dideoxyinosine

Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).

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Didanosine, CAS 69655-05-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 34.00
10 mg	In stock	$ 55.00
25 mg	In stock	$ 85.00
50 mg	In stock	$ 113.00
100 mg	In stock	$ 168.00
200 mg	In stock	$ 249.00
500 mg	In stock	$ 422.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 99.81%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
Targets&IC50	Reverse transcriptase:0.49 μM

Synonyms	ddI, 2',3'-Dideoxyinosine
Molecular Weight	236.23
Formula	C10H12N4O3
CAS No.	69655-05-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 44 mg/mL (186.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Benbrik E, et al. J Neurol Sci, 1997, 149(1), 19-25. 2. Perry CM, et al. Drugs, 1999, 58(6), 1099-1135. 3. Liu H, et al. Cell Biol Toxicol, 2008, 24(1), 113-121. 4. Chappell D, et al. Anesthesiology, 2007, 107(5), 776-784. 5. Walker UA, et al. Hepatology, 2004, 39(2), 311-317. 6. Fical L. Vývoj UHPLC-MS/MS metody pro analýzu vybraných antivirotik v HILIC a RP módu[J]. 2020 7. Fical L, Khalikova M, Kočová Vlčková H, et al. Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes[J]. Molecules. 2021, 26(8): 2123.

Citations

1. Fical L, Khalikova M, Kočová Vlčková H, et al. Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes. Molecules. 2021, 26(8): 2123.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library NO PAINS Compound Library Pediatric Drug Library Immunology/Inflammation Compound Library Orally Active Compound Library Drug-induced Liver Injury (DILI) Compound Library Bioactive Compounds Library Max Covalent Inhibitor Library FDA-Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Didanosine 69655-05-6 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase ddI antiretroviral Human immunodeficiency virus inhibit IEC-6 cells apoptosis orally active HIV Inhibitor 2',3'-Dideoxyinosine inhibitor

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