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Dihexa

Catalog No. T7376 CAS 1401708-83-5

Synonyms: PNB-0408, Hexanoyl-Tyr-Ile-Ahx-NH2, N-hexanoic-Try-Ile-(6)-amino hexanoic amide

Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) is an activator of the hepatocyte growth factor/c-Met (HGF/c-Met) system,it binds to HGF (Kd = 65 pM),and an analog of the peptide angiotensin IV.

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Dihexa, CAS 1401708-83-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 63.00
2 mg	In stock	$ 90.00
5 mg	In stock	$ 135.00
10 mg	In stock	$ 229.00
25 mg	In stock	$ 475.00
50 mg	In stock	$ 695.00
100 mg	In stock	$ 988.00
1 mL * 10 mM (in DMSO)	In stock	$ 233.00

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Purity: 98%

Biological Description

Chemical Properties

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Description	Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) is an activator of the hepatocyte growth factor/c-Met (HGF/c-Met) system,it binds to HGF (Kd = 65 pM),and an analog of the peptide angiotensin IV.
Targets&IC50	HGF:65 pM(kd)
In vivo	Dihexa (2 mg/kg, i.p.) completely reverses scopolamine-induced learning deficits in the latency to find the platform and increases the time spent in the target quadrant in the Morris water maze in rats[1]

Synonyms	PNB-0408, Hexanoyl-Tyr-Ile-Ahx-NH2, N-hexanoic-Try-Ile-(6)-amino hexanoic amide
Molecular Weight	504.66
Formula	C27H44N4O5
CAS No.	1401708-83-5

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (59.45 mM)

References and Literature

1. Mccoy A T , Benoist C C , Wright J W , et al. Evaluation of Metabolically Stabilized Angiotensin IV Analogs as Procognitive/Antidementia Agents[J]. Journal of Pharmacology and Experimental Therapeutics, 2013, 344(1):141-154. 2. Benoist C C , Kawas L H , Zhu M , et al. The Procognitive and Synaptogenic Effects of Angiotensin IV-Derived Peptides Are Dependent on Activation of the Hepatocyte Growth Factor/c-Met System[J]. Journal of Pharmacology and Experimental Therapeutics, 2014, 351(2):390-402.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Peptide Compound Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Cytokine Inhibitor Library NO PAINS Compound Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Lung Cancer Compound Library

Related Products

Related compounds with same targets

X-376 SYN1143 BMS817378 SRI 31215 TFA c-Kit-IN-1 BMS-2 NPS-1034 Tyrosine kinase-IN-6

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Dihexa 1401708-83-5 Tyrosine Kinase/Adaptors c-Met/HGFR N-hexanoic-Try-Ile-(6)-amino hexanoic Amide PNB-0408 PNB0408 Hexanoyl-Tyr-Ile-Ahx-NH2 N-hexanoic-Try-Ile-(6)-amino hexanoic amide PNB 0408 inhibitor inhibit

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