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ESI-08

Catalog No. T11234Cas No. 301177-43-5

ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.

ESI-08

ESI-08

Purity: 99.05%
Catalog No. T11234Cas No. 301177-43-5
ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.
Pack SizePriceAvailabilityQuantity
1 mg$51In Stock
5 mg$122In Stock
10 mg$198In Stock
25 mg$455In Stock
50 mg$672In Stock
1 mL x 10 mM (in DMSO)$168In Stock
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Purity:99.05%
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Product Introduction

Bioactivity
Description
ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.
Targets&IC50
EPAC2:8.4 μM
In vitro
ESI-08 (25 μM) does not alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1].
Chemical Properties
Molecular Weight353.48
FormulaC20H23N3OS
Cas No.301177-43-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (141.45 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8290 mL14.1451 mL28.2901 mL141.4507 mL
5 mM0.5658 mL2.8290 mL5.6580 mL28.2901 mL
10 mM0.2829 mL1.4145 mL2.8290 mL14.1451 mL
20 mM0.1415 mL0.7073 mL1.4145 mL7.0725 mL
50 mM0.0566 mL0.2829 mL0.5658 mL2.8290 mL
100 mM0.0283 mL0.1415 mL0.2829 mL1.4145 mL

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