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ESI-09
🥰Excellent
Catalog No. T2244Cas No. 263707-16-0
ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively.
ESI-09
🥰Excellent
Purity: 99.57%
Catalog No. T2244Cas No. 263707-16-0
ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $56 | In Stock | |
| 10 mg | $89 | In Stock | |
| 25 mg | $177 | In Stock | |
| 50 mg | $320 | In Stock | |
| 100 mg | $482 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $61 | In Stock |
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Purity:99.57%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively. |
| Targets&IC50 | EPAC1:3.2 μM, EPAC2:1.4 μM |
| In vitro | In WT C57BL/6 mice, ESI-09 (10 mg/kg/d, i.p.) prevents SFG Rickettsiosis by inhibiting EPAC1. |
| In vivo | ESI-09 specifically inhibits intracellular EPAC-mediated activation of Rap1 and phosphorylation of Akt, as well as EPAC-mediated secretion in pancreatic β-cells. In pancreatic cancer cells induced by 007-AM, ESI-09 reduces cell adhesion and inhibits cell migration. In Schwann cells stimulated by CPT-cAMP, ESI-09 significantly suppresses cell differentiation and myelination. Additionally, in SC neuronal cultures, ESI-09 notably decreases the number of O1-positive and MBP-positive cells. |
| Molecular Weight | 330.77 |
| Formula | C16H15ClN4O2 |
| Cas No. | 263707-16-0 |
| Smiles | CC(C)(C)c1cc(no1)C(=O)C(=NNc1cccc(Cl)c1)C#N |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 33.1 mg/mL (100 mM) Ethanol: 6.6 mg/mL (20 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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