store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 89.00 | |
2 mg | In stock | $ 143.00 | |
5 mg | In stock | $ 313.00 | |
10 mg | In stock | $ 493.00 | |
25 mg | In stock | $ 812.00 | |
50 mg | In stock | $ 1,130.00 | |
100 mg | In stock | $ 1,520.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 386.00 |
Description | Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface. |
In vitro | Elexacaftor (VX-445) has the potential to treat cystic fibrosis and it also is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore Phe508del CFTR protein function. VX-445-Tezacaftor-VX-770 significantly improves Phe508del CFTR protein processing, trafficking, chloride transport. To a greater extent than any two of these agents in dual combination[2]. |
Synonyms | VX-445 |
Molecular Weight | 597.65 |
Formula | C26H34F3N7O4S |
CAS No. | 2216712-66-0 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (209.15 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Elexacaftor 2216712-66-0 Autophagy Membrane transporter/Ion channel CFTR Fibrosis Cystic fibrosis transmembrane conductance regulator Inhibitor Cystic VX 445 inhibit VX445 VX-445 inhibitor