Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
2 mg | In stock | $ 46.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 117.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 328.00 | |
100 mg | In stock | $ 487.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 83.00 |
Description | Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment. |
Targets&IC50 | Factor prolyl hydroxylase:(EC50)0.22 μM |
In vitro | Enarodustat exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition. |
In vivo | Enarodustat (1 and 3 mg/kg, p.o., in rats) treatment increases hemoglobin levels in a dose-dependent manner. |
Synonyms | JTZ-951 |
Molecular Weight | 340.33 |
Formula | C17H16N4O4 |
CAS No. | 1262132-81-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (244.85 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Enarodustat 1262132-81-9 Chromatin/Epigenetic Metabolism Others HIF/HIF Prolyl-Hydroxylase HIFs inhibit HIF-PH Hypoxia-inducible factors JTZ951 JTZ-951 JTZ 951 Inhibitor inhibitor