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Epertinib hydrochloride

Epertinib hydrochloride
Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity. Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively.
Catalog No. T11213Cas No. 2071195-74-7
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Purity:99.14%
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Epertinib hydrochloride

Purity: 99.14%
Catalog No. T11213Alias S-22611 hydrochlorideCas No. 2071195-74-7

Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity. Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively.
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Pack SizePriceAvailabilityQuantity
1 mg$84In Stock
5 mg$198In Stock
10 mg$328In Stock
25 mg$562In Stock
50 mg$795In Stock
100 mg$1,070In Stock
500 mg$2,150In Stock
1 mL x 10 mM (in DMSO)$268In Stock
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Product Introduction

Bioactivity
Description
Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity. Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively.
Targets&IC50
EGFR:1.48 nM, HER4:2.49 nM, HER2:7.15 nM
AliasS-22611 hydrochloride
Chemical Properties
Molecular Weight596.48
FormulaC30H28Cl2FN5O3
Cas No.2071195-74-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 125 mg/mL (209.56 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6765 mL8.3825 mL16.7650 mL83.8251 mL
5 mM0.3353 mL1.6765 mL3.3530 mL16.7650 mL
10 mM0.1677 mL0.8383 mL1.6765 mL8.3825 mL
20 mM0.0838 mL0.4191 mL0.8383 mL4.1913 mL
50 mM0.0335 mL0.1677 mL0.3353 mL1.6765 mL
100 mM0.0168 mL0.0838 mL0.1677 mL0.8383 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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