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Etamicastat hydrochloride

Catalog No. T11238LCas No. 677773-32-9
Alias BIA 5-453 hydrochloride

Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.

Etamicastat hydrochloride

Etamicastat hydrochloride

Purity: 99.48%
Catalog No. T11238LAlias BIA 5-453 hydrochlorideCas No. 677773-32-9
Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.
Pack SizePriceAvailabilityQuantity
1 mg$129In Stock
5 mg$322In Stock
10 mg$479In Stock
25 mg$782In Stock
50 mg$1,070In Stock
100 mg$1,530In Stock
1 mL x 10 mM (in DMSO)$353In Stock
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Purity:99.48%
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Product Introduction

Bioactivity
Description
Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.
Targets&IC50
DBH:107 nM
In vitro
Etamicastat hydrochloride blocks the hERG current amplitude with an IC50 value of 44 μg/mL [1].
In vivo
Etamicastat hydrochloride (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat hydrochloride (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels[1].
Cell Research
Etamicastat blocks the hERG current amplitude with an IC50 value of 44 μg/mL .
Animal Research
Etamicastat (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels.
AliasBIA 5-453 hydrochloride
Chemical Properties
Molecular Weight347.81
FormulaC14H16ClF2N3OS
Cas No.677773-32-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 15.0 mg/mL (43.1 mM), Sonication is recommended.
DMSO: 90.0 mg/mL (258.8 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.8751 mL14.3757 mL28.7513 mL143.7566 mL
5 mM0.5750 mL2.8751 mL5.7503 mL28.7513 mL
10 mM0.2875 mL1.4376 mL2.8751 mL14.3757 mL
20 mM0.1438 mL0.7188 mL1.4376 mL7.1878 mL
DMSO
1mg5mg10mg50mg
50 mM0.0575 mL0.2875 mL0.5750 mL2.8751 mL
100 mM0.0288 mL0.1438 mL0.2875 mL1.4376 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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