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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $129 | In Stock | |
5 mg | $322 | In Stock | |
10 mg | $479 | In Stock | |
25 mg | $782 | In Stock | |
50 mg | $1,070 | In Stock | |
100 mg | $1,530 | In Stock | |
1 mL x 10 mM (in DMSO) | $353 | In Stock |
Description | Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension. |
Targets&IC50 | DBH:107 nM |
In vitro | Etamicastat hydrochloride blocks the hERG current amplitude with an IC50 value of 44 μg/mL [1]. |
In vivo | Etamicastat hydrochloride (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat hydrochloride (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels[1]. |
Cell Research | Etamicastat blocks the hERG current amplitude with an IC50 value of 44 μg/mL . |
Animal Research | Etamicastat (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels. |
Alias | BIA 5-453 hydrochloride |
Molecular Weight | 347.81 |
Formula | C14H16ClF2N3OS |
Cas No. | 677773-32-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 15.0 mg/mL (43.1 mM), Sonication is recommended. DMSO: 90.0 mg/mL (258.8 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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