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Etamicastat hydrochloride
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Purity:99.48%
Etamicastat hydrochloride
Catalog No. T11238LCas No. 677773-32-9
Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $129 | In Stock | |
| 5 mg | $322 | In Stock | |
| 10 mg | $479 | In Stock | |
| 25 mg | $782 | In Stock | |
| 50 mg | $1,070 | In Stock | |
| 100 mg | $1,530 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $353 | In Stock |
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension. |
| Targets&IC50 | DBH:107 nM |
| In vitro | Etamicastat hydrochloride blocks the hERG current amplitude with an IC50 value of 44 μg/mL [1]. |
| In vivo | Etamicastat hydrochloride (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat hydrochloride (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels[1]. |
| Cell Research | Etamicastat blocks the hERG current amplitude with an IC50 value of 44 μg/mL . |
| Animal Research | Etamicastat (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels. |
| Alias | BIA 5-453 hydrochloride |
| Molecular Weight | 347.81 |
| Formula | C14H16ClF2N3OS |
| Cas No. | 677773-32-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 15.0 mg/mL (43.1 mM), Sonication is recommended. DMSO: 90.0 mg/mL (258.8 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
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