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Ethoxzolamide

Catalog No. T5012 CAS 452-35-7

Synonyms: PNU-4191, Redupresin, L-643786

Ethoxzolamide (L-643786) is a carbonic anhydrase inhibitor.

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Ethoxzolamide, CAS 452-35-7

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5 mg	In stock	$ 33.00
10 mg	In stock	$ 44.00
25 mg	In stock	$ 68.00
50 mg	In stock	Inquiry

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Purity: 99.62%

Purity: 98.75%

Purity: 96.33%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ethoxzolamide (L-643786) is a carbonic anhydrase inhibitor.
Targets&IC50	CA:1nM(Ki）
In vitro	Ethoxzolamide (ETZ) treatment leads to a greater than 90% reduction in reporter GFP fluorescence in infected macrophages and markedly impairs the intracellular growth of M. tuberculosis, as demonstrated in a 9-day macrophage survival assay.

Synonyms	PNU-4191, Redupresin, L-643786
Molecular Weight	258.32
Formula	C9H10N2O3S2
CAS No.	452-35-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (580.68 mM), Sonication and heating are recommended.

References and Literature

1. Benjamin K. Johnson, et al. The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits theMycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence. Antimicrob Agents Chemother. 2015 Aug; 59(8): 4436–4445. 2. Song Gao, et al. Development and validation of an UPLC-MS/MS method for the quantification of ethoxzolamide in plasma and bioequivalent buffers: Applications to absorption, brain distribution, and pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 1; 0: 54–59. 3. Maren TH, et al. Relations among IOP reduction, ocular disposition and pharmacology of the carbonic anhydrase inhibitor ethoxzolamide. Exp Eye Res. 1992 Jul;55(1):73-9.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Approved Drug Library Anti-Infection Compound Library Bioactive Compound Library NO PAINS Compound Library FDA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-Bacterial Compound Library ReFRAME Related Library

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ethoxzolamide 452-35-7 Metabolism Microbiology/Virology Carbonic Anhydrase Antibacterial Carbonate dehydratase inhibit PNU-4191 Inhibitor PNU 4191 Bacterial PNU4191 Redupresin L 643786 L-643786 L643786 inhibitor

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