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Furanodiene

Catalog No. TN1651   CAS 19912-61-9
Synonyms: CD243, Pgp, ABCB1, Apoptosis, P-gp, Inhibitor, Multidrug resistance protein 1, inhibit, MDR1, Furanodiene, Cluster of differentiation 243, P-glycoprotein, Reactive Oxygen Species

Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Furanodiene, CAS 19912-61-9
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
In vitro The in vitro effects of Furanodiene were examined on two human breast cancer cell lines, MCF-7 and MDA-MB-231 cells. Assays of proliferation, LDH release, mitochondrial membrane potential (ΔΨm), cell cycle distribution, apoptosis and relevant signaling pathways were performed. The in vivo effect was determined with MCF7 tumor xenograft model in nude mice. Furanodiene significantly inhibited the proliferation and increased the LDH release in both cell lines in a dose-dependent manner. ΔΨm depolarization, chromatin condensation, and DNA fragmentation were also observed after Furanodiene treatment. Furanodiene dose-dependently induced cell cycle arrest at the G0/G1 phase. The protein expressions of p-cyclin D1, total cyclin D1, p-CDK2, total CDK2, p-Rb, total Rb, Bcl-xL, and Akt were significantly inhibited by Furanodiene, whereas the protein expressions of Bad and Bax, and the proteolytic cleavage of caspase-9, caspase-7, and poly-ADP-ribose polymerase (PARP) were dramatically increased. Furthermore, the z-VAD-fmk markedly reversed the Furanodiene-induced cell cytotoxicity, the proteolytic cleavage of caspase-9, and DNA fragmentation but did not affect the proteolytic cleavage of PARP, whereas the Akt inhibitor VIII increased the Furanodiene-induced cytotoxicity and PARP cleavage. In addition, Furanodiene dose-dependently suppressed the tumor growth in vivo, achieving 32% and 54% inhibition rates after intraperitoneal injection of 15 mg/kg and 30 mg/kg, respectively[1]
Synonyms CD243, Pgp, ABCB1, Apoptosis, P-gp, Inhibitor, Multidrug resistance protein 1, inhibit, MDR1, Furanodiene, Cluster of differentiation 243, P-glycoprotein, Reactive Oxygen Species
Molecular Weight 216.32
Formula C15H20O
CAS No. 19912-61-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo.Cell Physiol Biochem. 2012;30(3):778-90.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Terpene Natural Product Library Anti-Cardiovascular Disease Compound Library Immunology/Inflammation Compound Library Cell Cycle Compound Library Anti-Breast Cancer Compound Library Kinase Inhibitor Library Apoptosis Compound Library Epigenetics Compound Library Ferroptosis Compound Library

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