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GET73

Catalog No. T11393   CAS 202402-01-5
Synonyms: Gamma hydroxybutyric acid analogue, GET 73

GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.

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GET73 Chemical Structure
GET73, CAS 202402-01-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 128.00
5 mg In stock $ 272.00
10 mg In stock $ 437.00
25 mg In stock $ 723.00
50 mg In stock $ 987.00
100 mg In stock $ 1,380.00
500 mg In stock $ 2,760.00
1 mL * 10 mM (in DMSO) In stock $ 393.00
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Purity: 99.54%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.
In vitro GET73 (1 μM, 10 μM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, an increase of reactive oxygen species production?and a decrease in extracellular glutamate levels.
In vivo GET73 exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test.
Synonyms Gamma hydroxybutyric acid analogue, GET 73
Molecular Weight 275.27
Formula C13H16F3NO2
CAS No. 202402-01-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 97 mg/mL (352.38 mM), sonification is recommended.

TargetMolReferences and Literature

1. Tomasini MC, et al. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol. 2016 Mar;51(2):128-35. 2. Ferraro L, et al. GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. Pharmacol Rep. 2011;63(6):1359-71. 3. Loche A, et al. Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. Front Psychiatry. 2012 Feb 14;3:8.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Drug Repurposing Compound Library NO PAINS Compound Library Neuronal Signaling Compound Library Anti-Neurodegenerative Disease Compound Library Clinical Compound Library Bioactive Compound Library

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Keywords

GET73 202402-01-5 Neuroscience GluR neuroprotective anti-alcohol inhibit γ-hydroxybutyric acid mGluR5 GHB GET-73 Gamma hydroxybutyric acid analogue Inhibitor GET 73 anxiolytic glutamate inhibitor

 

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