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GS143

Catalog No. T25465 CAS 916232-21-8

Synonyms: GS-143, GS 143

GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect

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GS143, CAS 916232-21-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 140.00
25 mg	In stock	$ 288.00
50 mg	In stock	$ 455.00
100 mg	In stock	$ 677.00
500 mg	In stock	$ 1,430.00
1 mL * 10 mM (in DMSO)	In stock	$ 91.00

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Purity: 99.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect
Targets&IC50	IκBα phosphorylation:5.2 μM

Synonyms	GS-143, GS 143
Molecular Weight	466.46
Formula	C28H19FN2O4
CAS No.	916232-21-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (85.75 mM), Sonication is recommended.

References and Literature

1. Rashmi BS, Gayathri D. Molecular characterization of gluten hydrolysing Bacillus sp. and their efficacy and biotherapeutic potential as probiotics using Caco-2 cell line. J Appl Microbiol. 2017 Sep;123(3):759-772. doi: 10.1111/jam.13517. Epub 2017 Aug 4. PubMed PMID: 28637081. 2. Chen S, Wei YJ, Chen MM, Zhang ZT. Bilateral treatment: a strategy for enhancing the mechanical strength of machinable veneers. Dent Mater. 2010 Oct;26(10):961-7. doi: 10.1016/j.dental.2010.05.011. Epub 2010 Jul 23. PubMed PMID: 20655583. 3. Hirose K, Wakashin H, Oki M, Kagami S, Suto A, Ikeda K, Watanabe N, Iwamoto I, Furuichi Y, Nakajima H. GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice. Biochem Biophys Res Commun. 2008 Sep 26;374(3):507-11. doi: 10.1016/j.bbrc.2008.07.072. Epub 2008 Jul 24. PubMed PMID: 18656449. 4. Nakajima H, Fujiwara H, Furuichi Y, Tanaka K, Shimbara N. A novel small-molecule inhibitor of NF-kappaB signaling. Biochem Biophys Res Commun. 2008 Apr 18;368(4):1007-13. doi: 10.1016/j.bbrc.2008.01.166. Epub 2008 Feb 12. PubMed PMID: 18275844.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Bioactive Compounds Library Max NF-κB Signaling Compound Library Bioactive Compound Library Ubiquitination Compound Library Oxidation-Reduction Compound Library Anti-Lung Cancer Compound Library Immunology/Inflammation Compound Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets

Bakkenolide IIIa Cudraflavone B BMS-345541 hydrochloride Resveratrol NF-κB-IN-1 GSK8612 Rosmarinic acid WS6

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Keywords

GS143 916232-21-8 NF-Κb Ubiquitination IκB/IKK E1/E2/E3 Enzyme NF-κB E2 conjugating enzyme inhibit IκBα Th2 Ubiquitin conjugating enzyme Ubiquitin ligase IL-4 IκB kinase βTrCP1 Nuclear factor-kappaB eosinophil Ubiquitin activating enzyme Nuclear factor-κB I kappa B kinase E3 ligating enzyme GS-143 IKK E1 activating enzyme anti-asthma ubiquitination Inhibitor airway GS 143 inflammation inhibitor

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