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GSK3145095

Catalog No. T15437 CAS 1622849-43-7

GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.

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GSK3145095, CAS 1622849-43-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
2 mg	In stock	$ 148.00
5 mg	In stock	$ 288.00
10 mg	In stock	$ 490.00
25 mg	In stock	$ 783.00
50 mg	In stock	$ 1,090.00
100 mg	In stock	$ 1,480.00
1 mL * 10 mM (in DMSO)	In stock	$ 252.00

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Purity: 100%

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Description	GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
Targets&IC50	RIP1 kinase:6.3 nM (IC50)
In vitro	GSK3145095 potently binds to RIP1 with exquisite kinase specificity and has excellent activity in blocking RIP1 kinase-dependent cellular responses.?Highlighting its potential as a novel cancer therapy, the inhibitor was also able to promote a tumor suppressive T cell phenotype in pancreatic adenocarcinoma organ cultures.

Molecular Weight	397.38
Formula	C20H17F2N5O2
CAS No.	1622849-43-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 245 mg/mL (616.54 mM), Sonification is recommended.

References and Literature

1. Harris PA, ET AL. Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10(6):857-862.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Apoptosis Compound Library Anti-Liver Cancer Compound Library NO PAINS Compound Library Kinase Inhibitor Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets

Necrostatin-1 GSK481 RIPK2/3-IN-1 GSK547 ICCB-19 hydrochloride RIPK3-IN-4 GSK2983559 free acid RIP1 kinase inhibitor 5

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK3145095 1622849-43-7 Apoptosis NF-Κb RIP kinase GSK-3145095 Inhibitor inhibit GSK 3145095 Receptor-interacting protein kinases RIPK inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.