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GSK4112

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Catalog No. T5045Cas No. 1216744-19-2
Alias SR6452, 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 of 0.4 μM and serves as a small molecule chemical probe for studying the cell biology of the nuclear heme receptor Rev-erbα.

GSK4112

GSK4112

🥰Excellent
Purity: 99.63%
Catalog No. T5045Alias SR6452, 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinateCas No. 1216744-19-2
GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 of 0.4 μM and serves as a small molecule chemical probe for studying the cell biology of the nuclear heme receptor Rev-erbα.
Pack SizePriceAvailabilityQuantity
10 mg$46In Stock
25 mg$98In Stock
50 mg$178In Stock
100 mg$319In Stock
200 mg$459In Stock
1 mL x 10 mM (in DMSO)$30In Stock
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Purity:99.63%
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Product Introduction

Bioactivity
Description
GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 of 0.4 μM and serves as a small molecule chemical probe for studying the cell biology of the nuclear heme receptor Rev-erbα.
Targets&IC50
Rev-Erbα:0.4 μM(EC50)
In vitro
GSK4112 profiled as a Rev-erb agonist in cells to inhibit expression of the circadian target gene bmal1. In addition, GSK4112 repressed the expression of gluconeogenic genes in liver cells and reduced glucose output in primary hepatocytes. Therefore, GSK4112 is useful as a chemical tool to probe the function of Rev-erb in transcriptional repression, regulation of circadian biology, and metabolic pathways. Additionally, GSK4112 may serve as a starting point for design of Rev-erb chemical probes with in vivo pharmacologicalm activity.
AliasSR6452, 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
Chemical Properties
Molecular Weight396.89
FormulaC18H21ClN2O4S
Cas No.1216744-19-2
SmilesCC(C)(C)OC(=O)CN(Cc1ccc(s1)[N+]([O-])=O)Cc1ccc(Cl)cc1
Relative Density.1.296 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 9.9 mg/mL (25 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5196 mL12.5979 mL25.1959 mL125.9795 mL
5 mM0.5039 mL2.5196 mL5.0392 mL25.1959 mL
10 mM0.2520 mL1.2598 mL2.5196 mL12.5979 mL
20 mM0.1260 mL0.6299 mL1.2598 mL6.2990 mL

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