Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK4112 (SR6452) is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 43.00 | |
10 mg | In stock | $ 77.00 | |
25 mg | In stock | $ 163.00 | |
50 mg | In stock | $ 296.00 | |
100 mg | In stock | $ 531.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | GSK4112 (SR6452) is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. |
Targets&IC50 | Rev-erbα:0.4 μM(EC50) |
In vitro | GSK4112 profiled as a Rev-erb agonist in cells to inhibit expression of the circadian target gene bmal1. In addition, GSK4112 repressed the expression of gluconeogenic genes in liver cells and reduced glucose output in primary hepatocytes. Therefore, GSK4112 is useful as a chemical tool to probe the function of Rev-erb in transcriptional repression, regulation of circadian biology, and metabolic pathways. Additionally, GSK4112 may serve as a starting point for design of Rev-erb chemical probes with in vivo pharmacologicalm activity. |
Synonyms | 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate, SR6452 |
Molecular Weight | 396.89 |
Formula | C18H21ClN2O4S |
CAS No. | 1216744-19-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9.9 mg/mL(25 mM)
You can also refer to dose conversion for different animals. More
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GSK4112 1216744-19-2 Autophagy hepatic damage HepG2 SR 6452 Apoptosis mice Inhibitor gluconeogenesis bmal1 HDAC 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate GSK-4112 hepatic gene probe SR-6452 Jo2 inhibit Fas SR6452 GSK 4112 transcription inhibitor