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Globalagliatin

Catalog No. T3104 CAS 1234703-40-2

Synonyms: LY2608204

Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Globalagliatin, CAS 1234703-40-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 66.00
5 mg	In stock	$ 158.00
10 mg	In stock	$ 233.00
25 mg	In stock	$ 393.00
50 mg	In stock	$ 585.00

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Purity: 99.41%

ee: 100%

Purity: 98.26%

ee: 99.64%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
Targets&IC50	GK:42 nM(EC50)
In vitro	Under fasting and postprandial glucose conditions, LY2608204 demonstrated a dose-dependent reduction in blood glucose levels. Compared to the control group, the administration of a high dose of 30 mg/kg of the drug resulted in a maximum glucose-lowering effect of 42% on the glucose AUC. Interpolation analysis revealed that a 20% reduction in the glucose AUC occurred at an average LY2608204 concentration of 99 ng/mL (179 nM) in the plasma, equivalent to a dose of 6.9 mg/kg of LY2608204. The in vivo blood-brain barrier permeability of LY2608204 led to an average brain/plasma ratio of 0.17 and an average total brain level of 0.539 nmol/g, within 5 minutes.
In vivo	LY2608204 acts on rat insulinoma INS1-E cells, stimulating glucose metabolism with an EC50 of 579 nM. It activates glucokinase, presenting an EC50 of 42 nM in the presence of 10 mM glucose, demonstrating a concentration-dependent activation at lower glucose concentrations.

Synonyms	LY2608204
Molecular Weight	559.81
Formula	C28H37N3O3S3
CAS No.	1234703-40-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 33 mg/mL (58.9 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 103 mg/mL (184 mM)

References and Literature

1. Gupta, M., & Vadde, R. (2019). Insights into the structure–function relationship of both wild and mutant zinc transporter ZnT8 in human: a computational structural biology approach. Journal Of Biomolecular Structure And Dynamics, 1-15. doi: 10.1080/07391102.2019.1567391

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Clinical Compound Library Kinase Inhibitor Library NO PAINS Compound Library Target-Focused Phenotypic Screening Library Bioactive Compounds Library Max Glycometabolism Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Globalagliatin 1234703-40-2 Metabolism Glucokinase Hexokinase IV Inhibitor LY 2608204 Hexokinase D LY-2608204 inhibit LY2608204 inhibitor

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