Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 143.00 | |
25 mg | In stock | $ 289.00 | |
50 mg | In stock | $ 463.00 | |
100 mg | In stock | $ 668.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM). |
In vivo | HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells.?When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen. |
Molecular Weight | 377.83 |
Formula | C17H20ClN5O3 |
CAS No. | 1351758-81-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (132.33 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
HG-10-102-01 1351758-81-0 Autophagy LRRK2 Parkinson’s disease Leucine-rich repeat kinase 2 inhibit Ser910 BBB HG 10 102 01 Radiosynthesis Mouse embryonic fibroblast cells Mouse Swiss 3T3 cells MAP kinase interacting kinase Ser935 MNK Mitogen activated protein kinase interacting kinase HG1010201 PET Inhibitor MAPK interacting kinase HEK293 cells Positron emission tomography inhibitor