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HKI-357

HKI-357
HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation.
Catalog No. T11569Cas No. 848133-17-5
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Purity:95.11%
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HKI-357

Purity: 95.11%
Catalog No. T11569Cas No. 848133-17-5

HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$72In Stock
5 mg$155In Stock
10 mg$239In Stock
25 mg$487In Stock
50 mg$696In Stock
100 mg$987In Stock
1 mL x 10 mM (in DMSO)$197In Stock
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Product Introduction

Bioactivity
Description
HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation.
Targets&IC50
ErbB2:33 nM, EGFR:34 nM
In vitro
HKI-357 also is effective in suppressing EGFR autophosphorylation (measured at residue Y1068), and AKT and MAPK phosphorylation in parental NCI-H1650 cells harboring the delE746-A750 EGFR mutation.HKI-357 (0.01-10 μM) is effective in suppressing ligand-induced EGFR autophosphorylation and its downstream signaling, as determined by AKT and MAPK phosphorylation in NCI-H1975 cells.
Chemical Properties
Molecular Weight574.05
FormulaC31H29ClFN5O3
Cas No.848133-17-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (52.2 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7420 mL8.7100 mL17.4201 mL87.1004 mL
5 mM0.3484 mL1.7420 mL3.4840 mL17.4201 mL
10 mM0.1742 mL0.8710 mL1.7420 mL8.7100 mL
20 mM0.0871 mL0.4355 mL0.8710 mL4.3550 mL
50 mM0.0348 mL0.1742 mL0.3484 mL1.7420 mL

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