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HKI-357

Catalog No. T11569Cas No. 848133-17-5

HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation.

HKI-357

HKI-357

Purity: 95.11%
Catalog No. T11569Cas No. 848133-17-5
HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation.
Pack SizePriceAvailabilityQuantity
1 mg$72In Stock
5 mg$155In Stock
10 mg$239In Stock
25 mg$487In Stock
50 mg$696In Stock
100 mg$987In Stock
1 mL x 10 mM (in DMSO)$197In Stock
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Purity:95.11%
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Product Introduction

Bioactivity
Description
HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation.
Targets&IC50
ErbB2:33 nM, EGFR:34 nM
In vitro
HKI-357 also is effective in suppressing EGFR autophosphorylation (measured at residue Y1068), and AKT and MAPK phosphorylation in parental NCI-H1650 cells harboring the delE746-A750 EGFR mutation.HKI-357 (0.01-10 μM) is effective in suppressing ligand-induced EGFR autophosphorylation and its downstream signaling, as determined by AKT and MAPK phosphorylation in NCI-H1975 cells.
Chemical Properties
Molecular Weight574.05
FormulaC31H29ClFN5O3
Cas No.848133-17-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (52.2 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7420 mL8.7100 mL17.4201 mL87.1004 mL
5 mM0.3484 mL1.7420 mL3.4840 mL17.4201 mL
10 mM0.1742 mL0.8710 mL1.7420 mL8.7100 mL
20 mM0.0871 mL0.4355 mL0.8710 mL4.3550 mL
50 mM0.0348 mL0.1742 mL0.3484 mL1.7420 mL

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