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HPK1-IN-2

Catalog No. T9017 CAS 2056122-11-1

Synonyms: Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2, HPK1-IN-2

HPK1-IN-2 (Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2) is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1; IC50<0.05 μΜ). It also inhibits Lck (0.05 μΜ<IC50<0.5 μΜ) and Flt3 (IC50<0.05 μΜ) kinase activities with antitumor activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

HPK1-IN-2, CAS 2056122-11-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 118.00
5 mg	In stock	$ 243.00
10 mg	In stock	$ 405.00
25 mg	In stock	$ 676.00
50 mg	In stock	$ 962.00
100 mg	In stock	$ 1,280.00
500 mg	In stock	$ 2,590.00
1 mL * 10 mM (in DMSO)	In stock	$ 289.00

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Purity: 98.4%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HPK1-IN-2 (Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2) is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1; IC50<0.05 μΜ). It also inhibits Lck (0.05 μΜ<IC50<0.5 μΜ) and Flt3 (IC50<0.05 μΜ) kinase activities with antitumor activity.
Targets&IC50	FLT3:<0.05 µΜ , HPK1:IC50<0.05 µΜ, Lck:0.05 µΜ<IC50<0.5 µΜ
In vitro	In a-CD3 stimulated Jurkat E6. 1 cells, HPK1-IN-2 inhibits SLP76 serine 376 phosphorylation and ERK1/2 T202/Y204 phosphorylation with IC50 values of 0.3-1 μΜ and >3μΜ, respectively.
In vivo	HPK1-IN-2 (75-150 mg/kg; oral gavage; daily; for 21 days) treatment shows a dose-dependently tumor growth inhibition, with 75 mg/kg and 150 mg/kg QD inhibiting tumour growth by 44% and 64%, respectively

Synonyms	Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2, HPK1-IN-2
Molecular Weight	380.47
Formula	C19H20N6OS
CAS No.	2056122-11-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 25 mg/mL (55.14 mM), Sonication is recommended.

References and Literature

1. Peter Brent Sampson, et al. Hpk1 inhibitors and methods of using same. WO2016205942A1.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Inhibitor Library Anti-Cancer Compound Library Angiogenesis related Compound Library Bioactive Compound Library Bioactive Compounds Library Max Orally Active Compound Library Anti-Cancer Metabolism Compound Library Anti-Pancreatic Cancer Compound Library

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Keywords

HPK1-IN-2 2056122-11-1 Angiogenesis Others Tyrosine Kinase/Adaptors FLT Src Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2 HPK1 IN 2 dihydrochloride HPK-1-IN-2 dihydrochloride HPK1IN2 dihydrochloride inhibitor inhibit

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