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IMP-1088
IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.
Catalog No. T9350Cas No. 2059148-82-0
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Purity:99.08%
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IMP-1088
Catalog No. T9350Cas No. 2059148-82-0
IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $147 | In Stock | |
| 2 mg | $198 | In Stock | |
| 5 mg | $297 | In Stock | |
| 10 mg | $493 | In Stock | |
| 25 mg | $877 | In Stock | |
| 50 mg | $1,180 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $327 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual. |
| Targets&IC50 | NMT2 (human):<1 nM, NMT1 (human):<1 nM |
| In vitro | IMP-1088 (1-1000 nM) inhibits production of infectious virus and single-cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 hours, and remains effective even when administered up to 3 hours post-infection[1]. Additionally, IMP-1088 (500 nM) blocks virus assembly and inhibits production of infectious rhinovirus particles in HeLa cells infected with rhinovirus RV-A16 (MOI 20) for 6 hours[1]. |
| Molecular Weight | 453.53 |
| Formula | C25H29F2N5O |
| Cas No. | 2059148-82-0 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 95 mg/mL (209.47 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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