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IMR-1A

Catalog No. T3540Cas No. 331862-41-0

IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.

IMR-1A

IMR-1A

Purity: 99.06%
Catalog No. T3540Cas No. 331862-41-0
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
Pack SizePriceAvailabilityQuantity
1 mg$68In Stock
5 mg$163In Stock
10 mg$263In Stock
25 mg$393In Stock
50 mg$529In Stock
100 mg$795In Stock
1 mL x 10 mM (in DMSO)$167In Stock
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Purity:99.06%
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Product Introduction

Bioactivity
Description
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
Targets&IC50
IMR-1:6 μMol/L.
In vitro
IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth. A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO).
In vivo
The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish.
Chemical Properties
Molecular Weight325.36
FormulaC13H11NO5S2
Cas No.331862-41-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.23 mg/mL (13 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0735 mL15.3676 mL30.7352 mL153.6759 mL
5 mM0.6147 mL3.0735 mL6.1470 mL30.7352 mL
10 mM0.3074 mL1.5368 mL3.0735 mL15.3676 mL

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