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ISRIB (trans-isomer)

Catalog No. T6183 CAS 1597403-47-8

Synonyms: ISRIB, ISRIB trans-isomer, trans-isomer, trans-ISRIB

ISRIB (trans-isomer) (ISRIB trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).

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ISRIB (trans-isomer), CAS 1597403-47-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 41.00
5 mg	In stock	$ 66.00
10 mg	In stock	$ 100.00
25 mg	In stock	$ 196.00
50 mg	In stock	$ 343.00
100 mg	In stock	$ 618.00
500 mg	In stock	$ 1,330.00

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Purity: 99.27%

Purity: 98.81%

Biological Description

Chemical Properties

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Description	ISRIB (trans-isomer) (ISRIB trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
Targets&IC50	PERK:5 nM
In vitro	ISRIB blocks production of endogenous ATF4, whereas XBP1 mRNA splicing and XBP1s production persisted. ISRIB prevents cells from re-establishing ER homeostasis by blocking signaling through the PERK branch of the UPR, and decreases the viability of cells that are subjected to ER-stress. [1]
In vivo	ISRIB shows favorable properties in pharmacokinetic profiling experiments and good bioavailability in vivo. ISRIB (0.25 mg/kg i.p.) increases long-term memory in mice by enhancing spatial and fear-associated learning. [1]
Cell Research	U2OS cells are plated on 96-well plates and left to recover overnight. Cells are treated with either with 2 μg/ml tunicamycin or 100 nM thapsigargin in the presence or absence of 100 nM ISRIB or with ISRIB alone for the indicated and the level of eIF2α phosphorylation is determined[1].

Synonyms	ISRIB, ISRIB trans-isomer, trans-isomer, trans-ISRIB
Molecular Weight	451.34
Formula	C22H24Cl2N2O4
CAS No.	1597403-47-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1.11 mg/mL (2.46 mM), Sonication is recommended.

References and Literature

1. Sidrauski C, et al. Elife. 2013, 2, e00498.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Inhibitor Library Kinase Inhibitor Library Anti-Pancreatic Cancer Compound Library NO PAINS Compound Library Anti-Aging Compound Library Anti-Cancer Compound Library Anti-Obesity Compound Library MAPK Inhibitor Library Bioactive Compound Library

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Keywords

ISRIB (trans-isomer) 1597403-47-8 Apoptosis Autophagy PERK ISRIB ISRIB (trans isomer) ISRIB (transisomer) ISRIB trans-isomer PKR-like endoplasmic reticulum kinase trans-isomer trans-ISRIB Inhibitor Protein kinase R-like endoplasmic reticulum kinase inhibit inhibitor

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