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Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 mg | $50 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Isoliquiritigenin (ISL), an anti-tumor flavonoid from the root of Glycyrrhiza glabra, suppresses aldose reductase (IC50=320 nM). |
In vitro | In the murine oral administration test, the LD50 of Isoliquiritigenin is greater than 6 g/kg. |
In vivo | Isoliquiritigenin induces cell cycle arrest and inhibits cell growth in DU145 and LNCaP cell lines. In human gastric cancer MGC-803 cells, isoliquiritigenin triggers apoptosis by elevating intracellular free calcium ion concentrations and decreasing mitochondrial membrane potential (Δψ(m)). |
Alias | ISL, Isoliquiritigen, GU17 |
Molecular Weight | 256.25 |
Formula | C15H12O4 |
Cas No. | 961-29-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | 5% DMSO+95% Saline: 2.55 mg/mL (9.95 mM, precipitation) ![]() DMSO: 60 mg/mL (234.15 mM) ![]() Ethanol: 22 mg/mL(85.9 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/5% DMSO+95% Saline
DMSO
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