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Isoliquiritigenin
🥰Excellent
Catalog No. T0725Cas No. 961-29-5
Alias Isoliquiritigen, ISL, GU17
Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity.
Isoliquiritigenin
🥰Excellent
Purity: 99.44%
Catalog No. T0725Alias Isoliquiritigen, ISL, GU17Cas No. 961-29-5
Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 mg | $50 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.44%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity. |
| Targets&IC50 | Aldose reductase:320 nM |
| In vitro | METHODS: Normal human hepatocyte cell line LO2 and HCC cell line Hep3B were treated with Isoliquiritigenin (30-60 µM) for 24-72 h. Cell viability was measured by MTT assay. RESULTS: Isoliquiritigenin showed significant cytotoxicity against Hep3B cells with an IC50 of 42.84±2.01 µM at 48 h. This effect was concentration and time dependent. However, at the same Isoliquiritigenin stimulation intensity, the survival of LO2 cells was significantly less affected with an IC50 >60 µM.[1] METHODS: Human colorectal cancer cells HCT-116 were treated with Isoliquiritigenin (20 µM) for 24 h. Apoptosis was detected by Flow cytometry. RESULTS: Treatment of HCT-116 cells with Isoliquiritigenin resulted in a significant increase in apoptosis (17.26%) in the treated group compared to the NC group (7.37%). [2] |
| In vivo | METHODS: To assay anti-tumor activity in vivo, Isoliquiritigenin (50 mg/kg) was injected intraperitoneally into BALB/c-nu/nu mice bearing Hep3B xenografts once daily for three weeks. RESULTS: Isoliquiritigenin-treated mice had reduced tumor burden in terms of mean tumor size or xenograft weight. [1] |
| Alias | Isoliquiritigen, ISL, GU17 |
| Molecular Weight | 256.25 |
| Formula | C15H12O4 |
| Cas No. | 961-29-5 |
| Smiles | C(/C=C/C1=CC=C(O)C=C1)(=O)C2=C(O)C=C(O)C=C2 |
| Relative Density. | 1.384 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.1 mg/mL (19.9 mM), In vivo: Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.  DMSO: 60 mg/mL (234.15 mM) Ethanol: 22 mg/mL (85.9 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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