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JR-AB2-011

Catalog No. T11728Cas No. 2411853-34-2

JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. It inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM) and exhibits cytotoxicity in glioblastoma [1].

JR-AB2-011

JR-AB2-011

Purity: 98.87%
Catalog No. T11728Cas No. 2411853-34-2
JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. It inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM) and exhibits cytotoxicity in glioblastoma [1].
Pack SizePriceAvailabilityQuantity
1 mg$87In Stock
5 mg$213In Stock
10 mg$363In Stock
25 mg$663In Stock
50 mg$995In Stock
100 mg$1,330In Stock
1 mL x 10 mM (in DMSO)$235In Stock
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Purity:98.87%
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Product Introduction

Bioactivity
Description
JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. It inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM) and exhibits cytotoxicity in glioblastoma [1].
Targets&IC50
mTORC2:0.36 μM
In vitro
JR-AB2-011 (1 μM; 24 hours) shows good anti-GBM properties, blocks mTORC2 signaling and Rictor association with mTOR [1]. JR-AB2-011 (0.5-2 μM; 48 hours) displays the least toxicity to normal neurons with no significant cytotoxic effects for concentrations up to 10 mM compared to CID613034 [1]. Apoptosis Analysis [1] Cell Line: U87 GBM cells; LN229 GBM cells Concentration: 1 μM Incubation Time: 24 hours Result: Had good anti-GBM properties and blocked mTORC2 signaling and Rictor association with mTOR. Cell Cytotoxicity Assay [1] Cell Line: Normal mature human neurons Concentration: 0.5, 1, 2 μM Incubation Time: 48 hours Result: Displayed the least toxicity to normal neurons with no significant cytotoxic effects for concentrations up to 10 mM.
In vivo
Mice administered JR-AB2-011 through intraperitoneal injection at doses of 4 mg/kg or 20 mg/kg daily for 10 days exhibited significant suppression of tumor growth compared to those treated with a vehicle control. Specifically, the lower dose achieved a 74% reduction in tumor growth rate with a 10-day delay in tumor progression, while the higher dose resulted in an 80% reduction and a 12-day delay. This study utilized female C.B.-17-scid mice implanted with LN229 cells, demonstrating that JR-AB2-011 is potent in inhibiting tumor growth at both tested concentrations.
Chemical Properties
Molecular Weight398.28
FormulaC17H14Cl2FN3OS
Cas No.2411853-34-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 61.5 mg/mL (154.41 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5108 mL12.5540 mL25.1080 mL125.5398 mL
5 mM0.5022 mL2.5108 mL5.0216 mL25.1080 mL
10 mM0.2511 mL1.2554 mL2.5108 mL12.5540 mL
20 mM0.1255 mL0.6277 mL1.2554 mL6.2770 mL
50 mM0.0502 mL0.2511 mL0.5022 mL2.5108 mL
100 mM0.0251 mL0.1255 mL0.2511 mL1.2554 mL

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