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K-7174

Catalog No. T11742 CAS 191089-59-5

K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.

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K-7174, CAS 191089-59-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 78.00
5 mg	In stock	$ 159.00
10 mg	In stock	$ 239.00
25 mg	In stock	$ 477.00
50 mg	In stock	$ 698.00
100 mg	In stock	$ 993.00

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Purity: 98.55%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.

Molecular Weight	568.74
Formula	C33H48N2O6
CAS No.	191089-59-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 5.69 mg/mL (10 mM)

References and Literature

1. Umetani M, et al. A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA. Biochem Biophys Res Commun. 2000 Jun 7;272(2):370-4. 2. Imagawa S, et al. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA. FASEB J. 2003 Sep;17(12):1742-4. 3. Shimada T, et al. Unexpected blockade of adipocyte differentiation by K-7174: implication for endoplasmic reticulum stress. Biochem Biophys Res Commun. 2007 Nov 16;363(2):355-60. 4. Kikuchi J, et al. The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases. J Biol Chem. 2013 Aug 30;288(35):25593-602.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Immuno-Oncology Compound Library Cytokine Inhibitor Library Anti-Aging Compound Library Bioactive Compound Library Angiogenesis related Compound Library NF-κB Signaling Compound Library Anti-Cardiovascular Disease Compound Library NO PAINS Compound Library

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Keywords

K-7174 191089-59-5 Apoptosis Immunology/Inflammation IL Receptor TNF K7174 K 7174 inhibit Inhibitor inhibitor

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