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KN-93 Phosphate

Catalog No. T2606 CAS 1913269-12-1

KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II with K i of 370 nM. KN-93 phosphate inhibits serum-induced fibroblast cell growth in a comparable dose-dependent fashion to its inhibition of CaMK-II activity.

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KN-93 Phosphate, CAS 1913269-12-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 147.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 553.00
100 mg	In stock	$ 798.00
500 mg	In stock	$ 1,590.00
1 mL * 10 mM (in DMSO)	In stock	$ 142.00

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Purity: 99.93%

Purity: 99.87%

Purity: 99.58%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II with K i of 370 nM. KN-93 phosphate inhibits serum-induced fibroblast cell growth in a comparable dose-dependent fashion to its inhibition of CaMK-II activity.
Targets&IC50	CaMK II:0.37 μM(Ki)
In vitro	Following a 2-day exposure to KN-93, 95% of cells were found to be halted in the G1 phase of the cell cycle, a condition that is reversible as evidenced by the progression of cells into the S and G2-M phases a day after cessation of KN-93 treatment. Additionally, KN-93 inhibits cell proliferation induced by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. It also counteracts the activity of H+, K+-ATPase and disrupts the proton gradient across gastric membrane vesicles, ultimately leading to a decrease in the luminal space volume. Moreover, at a concentration of 0.5 μM, KN-93 prevents the increase in left ventricular developed pressure during action potential prolongation and early afterdepolarizations, a phenomenon associated with a rise in Ca2+-independent CaM kinase activity, which is inhibited by pre-treatment with KN-93.

Molecular Weight	599.03
Formula	C26H32ClN2O8PS
CAS No.	1913269-12-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 93 mg/mL (155.3 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 84 mg/mL (140.2 mM)

References and Literature

1. Sumi M, et al. Biochem Biophys Res Commun. 1991, 181(3), 968-975. 2. Tombes RM, et al. Cell Growth Differ. 1995, 6(9), 1063-1070. 3. Rokhlin OW, et al. Cancer Biol Ther. 2010, 9(3), 224-235. 4. Yang X, et al. Neuropsychiatr Dis Treat. 2013, 9, 1213-1220. 5. Koga T, et al. Autoimmunity. 2014, 15, 1-6.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Wnt/Hedgehog/Notch Compound Library Autophagy Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Target-Focused Phenotypic Screening Library Apoptosis Compound Library Neuronal Signaling Compound Library

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Syntide 2 acetate(108334-68-5 free base) Calmodulin Kinase IINtide, Myristoylated A-3 hydrochloride Autocamtide-2-related inhibitory peptide W-13 hydrochloride CaMKIIα-PHOTAC CALP2 acetate(261969-04-4 free base) STO-609

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Keywords

KN-93 Phosphate 1913269-12-1 Neuroscience CaMK KN 93 Phosphate KN93 Phosphate inhibitor inhibit

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